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Lipid-polymer membranes as carriers for L-tryptophan: molecular and metabolic properties
(Scientific Research, 2013-03)
Polymerized liposomes encapsulating L-tryptophan were studied with the aim to characterize them as drug delivery systems for the treatment of several metabolic diseases that need an increased systemic L-tryptophan ...
Exploratory conformational analysis of N-acetyl-L-tryptophan-N-methylamide. An ab initio study
(Elsevier Science, 2003-08-01)
The full conformational space of N-acetyl-L-tryptophan-N-methylamide was explored by ab initio MO computations. On the Ramachandran hypersurface of four independent variables E = E(φ, Ψ, χ1, χ2), 36 conformers were located ...
Hepatic alteration of tryptophan metabolism in an acute porphyria model. Its relation with gluconeogenic blockage
(Pergamon-Elsevier Science Ltd, 2008-02)
This study focuses on the alterations suffered by the serotoninergic and kinurenergic routes of tryptophan (TRP) metabolism in liver, and their relation with gluconeogenic phosphoenolpyruvate-carboxykinase (PEPCK) blockage ...
Optical studies of single-tryptophan B. licheniformis β-lactamase variants
(Elsevier Science, 2010-10)
β-lactamases (penicillinases) are important complicating factors in bacterial infections and excellent theoretical and experimental models in protein structure, dynamics and evolution. Bacillus licheniformis exo-small ...
Dietary l-tryptophan modulates agonistic behavior and brain serotonin in male dyadic contests of a cichlid fish
(Springer, 2019-12)
Although some studies have investigated the effects of dietary l-tryptophan on agonistic behavior, research on adult fish specimens is still lacking. Moreover, submissive behaviors have been generally overlooked. We focused ...
The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2,3-dioxygenase as revealed by quantum mechanical/molecular mechanical studies
(Springer, 2010-08)
Tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) are two heme-containing enzymes which catalyze the conversion of L-tryptophan to N-formylkynurenine (NFK). In mammals, TDO is mostly expressed in liver and ...
Molecular basis for the substrate stereoselectivity in tryptophan dioxygenase
(American Chemical Society, 2011-11-23)
Tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) are the only two heme proteins that catalyze the oxidation reaction of tryptophan (Trp) to Nformylkynurenine.<br />While human IDO is able to oxidize both ...
The autoimmune response elicited by mouse hepatitis virus (mhv-a59) infection is modulated by liver tryptophan-2,3- dioxygenase (tdo)
(Elsevier Science, 2019-11)
In a previous work we demonstrated that inhibition of mouse indoleamine 2,3-dioxygenase (IDO) by methyltryptophan (MT) exacerbated the pathological actions of mouse hepatitis virus (MHV-A59) infection, suggesting that ...
Inductive effects in amino acids and peptides: Ionization constants and tryptophan fluorescence
(Elsevier, 2020-12)
Although inductive effects in organic compounds are known to influence chemical properties such as ionization constants, their specific contribution to the properties/behavior of amino acids and functional groups in peptides ...
Role of tryptophan residues in the toxicity and photosensitized inactivation of escherichia coli α-hemolysin
(American Chemical Society, 2020-10-27)
α-Hemolysin (HlyA) is an extracellular protein toxin secreted by uropathogenic strains of Escherichia coli that inserts into membranes of eukaryotic cells. The main goal of this work was to investigate the involvement of ...