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Molecular characterization of IPNV RNA replication intermediates during the viral infective cycle
(2009)
Infectious Pancreatic Necrosis Virus (IPNV) is a bisegmented, double-stranded RNA virus, which belongs to the Birnaviridae family. In the current study, we have analyzed the RNA replication intermediates (RI) purified ...
Antiviral activity of phosphonoformate on rotavirus transcription and replication
(1995)
The antiviral effect of foscarnet (PFA) on the replication of rotavirus, a member of the Reoviridae, was studied. The pyrophosphate analogue is an effective inhibitor of several viral polymerases acting on the enzyme ...
Plant chromatin replicated in the absence of protein synthesis
(1983)
The aim of the present work is to detect possible differences in the chromatin of plants replicated in the absence of protein synthesis.The kinetics of nuclease digestion in Allium cepa L., evaluated after making the cells ...
RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune Signaling
(MDPI, 2021)
DDX3 is a cellular ATP-dependent RNA helicase involved in different aspects of RNA metabolism ranging from transcription to translation and therefore, DDX3 participates in the regulation of key cellular processes including ...
Bleomycin-induced γH2AX foci map preferentially to replicating domains in CHO9 interphase nuclei
(Kluwer Academic Publishers, 2014)
© 2014, Springer Science+Business Media Dordrecht.Exposure to DNA damaging agents triggers phosphorylation of histone variant H2AX (generating γH2AX) in large chromatin regions flanking DNA lesions, allowing their ...
Epitranscriptomic regulation of viral replication
(Elsevier B.V., 2017)
© 2017 RNA plays central roles in biology and novel functions and regulation mechanisms are constantly emerging. To accomplish some of their functions within the cell, RNA molecules undergo hundreds of chemical modifications ...
Replication of a chronic hepatitis B virus genotype F1b construct
(Springer, 2016)
Genotype F is one of the less-studied genotypes
of human hepatitis B virus, although it is widely distributed
in regions of Central and South American. Our previous
studies have shown that HBV genotype F is prevalent ...
Perturbation of endoplasmic reticulum homeostasis facilitates prion replication
(2007)
Prion diseases are fatal and infectious neurodegenerative disorders characterized by the accumulation of an abnormally folded form of the prion protein ( PrP), termed PrPSc. Prion replication triggers endoplasmic reticulum ...
Expression, functionality, and localization of apurinic/apyrimidinic endonucleases in replicative and non-replicative forms of Trypanosoma cruzi
(2014)
Trypanosoma cruzi is the etiological agent of Chagas disease. The parasite has to overcome oxidative damage by ROS/RNS all along its life cycle to survive and to establish a chronic infection. We propose that T. cruzi is ...
Crosstalk between RNA metabolism and cellular stress responses during Zika virus replication
(MDPI, 2020)
Zika virus (ZIKV) is a mosquito-borne virus associated with neurological disorders such as
Guillain-Barré syndrome and microcephaly. In humans, ZIKV is able to replicate in cell types from
di erent tissues including ...