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Hyaluronan oligomers sensitize chronic myeloid leukemia cell lines to the effect of imatinib
(Oxford University Press, 2016-04)
Chronic myeloid leukemia is a myeloproliferative syndrome characterized by the presence of the Philadelphia chromosome (Ph), generated by a reciprocal translocation occurring between chromosomes 9 and 22 [t(9;22)(q34;q11)]. ...
Specific assessment of BCR-ABL transcript overexpression and imatinib resistance in chronic myeloid leukemia patients
(Wiley Blackwell Publishing, Inc, 2009-04)
Imatinib mesylate has proven to be the most effective treatment in chronic myeloid leukemia. Nevertheless, imatinib resistance has raised concern and prompted interest in additional strategies to achieve disease eradication. ...
Single nucleotide polymorphism in PTEN-Long gene : a risk factor in chronic myeloid leukemia
(Elsevier, 2019-04-30)
The BCR-ABL1 oncogene is associated with chronic myeloid leukemia (CML) pathogenesis, but the molecular mechanisms that initiate leukemogenesis are still unclear. Cancer pathogenesis has been associated with genetic ...
Expression of LYN and PTEN genes in chronic myeloid leukemia and their importance in therapeutic strategy
(Elsevier Inc, 2013-10)
Tyrosine kinase inhibitors (TKIs), imatinib, nilotinib and dasatinib, are the current treatment of chronic myeloid leukemia (CML). BCR-ABL1 point mutations are the principal cause of resistance to treatment; however other ...
Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells
(Elsevier Science, 2020-01)
Targeting the apoptosis machinery is a promising therapeutic approach in myeloid malignancies. BCL2L1 is a well-known glucocorticoid-responsive gene and a key apoptosis regulator that, when over-expressed, can contribute ...
Histamine H2 receptor in blood cells: a suitable target for the treatment of acute myeloid leukemia
(Springer, 2016-06-18)
Acute myeloid leukemia (AML) consists in a cancer of early hematopoietic cells arising in the bone marrow, most often of those cells that would turn into white blood cells (except lymphocytes). Chemotherapy is the treatment ...
The dynamic of TNF and IL6 gene expression in chronic myeloid leukemia patients reveals early responders to imatinib⋆
(Pergamon-Elsevier Science Ltd, 2019-09)
Imatinib, the first BCR-ABL1 tyrosine kinase inhibitor (TKI), revolutionized the management of chronic myeloid leukemia (CML) and remains as the preferred first-line therapy for newly diagnosed patients [1]. Besides its ...