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Correlation between charge movement and ionic current during slow inactivation in Shaker K+ channels
(ROCKEFELLER UNIV PRESS, 1997-11)
Prolonged depolarization induces a slow inactivation process in some Ki channels. We have studied ionic and gating currents during long depolarizations in the mutant Shaker H4-Delta(6-46) K+ channel and in the nonconducting ...
Pore accessibility during C-type inactivation in Shaker K+ channels
(1998)
Shaker K+ channels inactivate through two distinct molecular mechanisms: N-type, which involves the N-terminal domain and C-type that appears to involve structural modifications at the external mouth of the channel. We ...
Analysis of the variability in microbial inactivation by acid treatments
(Elsevier, 2016)
The variability in microbial inactivation through acid treatments was evaluated in the present study. Enterococcus faecalis, Listeria innocua, Salmonella enterica, and Pseudomonas fluorescens were inoculated in buffered ...
A conducting state with properties of a slow inactivated state in a Shaker K+ channel mutant
(ROCKEFELLER UNIV PRESS, 2001-02)
In Shaker K+ channel, the amino terminus deletion Delta6-46 removes fast inactivation (N-type) unmasking a slow inactivation process. In Shaker Delta6-46 (Sh-IR) background, two additional mutations (T449V-I470C) remove ...
Long-lasting, reversible and non-neurotoxic inactivation of hippocampus activity induced by neosaxitoxin
(Elsevier B.V., 2018)
© 2018 Elsevier B.V. Background: Neosaxitoxin (NeoSTX) and related paralytics shellfish toxins has been successfully used as local anesthetic and muscle relaxants to treat a variety of ailments. The primary mechanism of ...
The influence of diet on liver phosphorylase. III. Role of inactivation on the decrease of phosphorylase under certain dietary conditions
(1962)
The addition of epinephrine to the incubation medium did not modify significantly and regularly the phosphorylase activity of liver slices prepared from well-fed or fasted rats. Liver phosphorylase was rapidly inactivated ...
Distinct mutations led to inactivation of type 1 fimbriae expression in Shigella spp
(Public Library of Science, 2015)
Shigella spp. are responsible for bacillary dysentery in humans. The acquisition or the modification of the virulence plasmid encoding factors promoting entry of bacteria into and dissemination within epithelial cells was ...
Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation
(Reino Unido, 2022-06-07)
Theta is one of the most prominent extracellular synchronous oscillations in the mammalian brain. Hippocampal theta relies on an intact medial septum (MS) and has been consistently recorded during the training phase of ...
Lysozyme inactivation by free radicals can occur independently of reactive carbonyl formation
(1997)
The relationship between the free radical-induced loss of lysozyme activity and the occurrence of oxidative modifications, evidenced as gain in DNPHreactive carbonyl groups (CO) and loss of tryptophan-associated fluorescence ...
Haplotype Analysis of the Promoter Region of Phosphodiesterase Type 8B (PDE8B) in Correlation with Inactivating PDE8B Mutation and the Serum Thyroid-Stimulating Hormone Levels
(Mary Ann Liebert, Inc., 2010)
Background: Human phosphodiesterase (PDE) type 8B (PDE8B) is located at 5q14.1 and is known as the PDE
with the highest affinity to cAMP. We recently described a family with bilateral micronodular adrenocortical
disease ...