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MIR-16 mediates trastuzumab and lapatinib response in ERBB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1.
(2016)
ErbB-2 amplification/overexpression accounts for an aggressive breast cancer (BC) subtype (ErbB-2-positive). Enhanced ErbB-2 expression was also found in gastric cancer (GC) and has been correlated with poor clinical ...
Interleukin-6 and neuregulin-1 as regulators of utrophin expression via the activation of nrg-1/erbb signaling pathway in mdx cells
(2017)
Duchenne muscular dystrophy (DMD) is a neuromuscular disease originated by mutations in the dystrophin gene. A promising therapeutic approach deals with functional substitution of dystrophin by utrophin, a structural homolog ...
The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer
(2017)
Gallbladder cancer (GBC) is a highly fatal disease with poor prognosis and few therapeutic alternatives. Molecular profiling has revealed that the deregulation in the ERK/MAPK signaling pathway plays a crucial role in many ...