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Reliable local dynamics in the brain across sessions are revealed by whole-brain modeling of resting state activity
(Wiley-liss, div John Wiley & Sons Inc., 2019-03)
Resting state fMRI is a tool for studying the functional organization of the human brain. Ongoing brain activity at “rest” is highly dynamic, but procedures such as correlation or independent component analysis treat ...
24S‐hydroxycholesterol: cellular effects and variations in brain diseases
(Wiley Blackwell Publishing, Inc, 2020-05)
The adult brain exhibit a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme Cytochrome P450 46A1 (CYP46A1) or ...
Perturbation of whole-brain dynamics in silico reveals mechanistic differences between brain states
(Academic Press, 2018-04)
Human neuroimaging research has revealed that wakefulness and sleep involve very different activity patterns. Yet, it is not clear why brain states differ in their dynamical complexity, e.g. in the level of integration and ...
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
(Pergamon-Elsevier Science Ltd, 2001-01)
Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival ...
The World´s Most Complex Puzzle
(TWAS, 2015-11)
Global brain research projects, supported by powerful new imaging technology, make neuroscience a promising field for young researchers.
Region-specific changes in Mus musculus brain size and cell composition under chronic nutrient restriction
(Company of Biologists, 2019-09)
Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the ...
The Brain and the Self in the Comprehensive Realism of Donald M. Mackay
(Università della Santa Croce, 2017-12)
The brain, the mind and the self are usually described as separate entities, although we intuitively recognize that they share some kind of relationship. The puzzle, however, begins when one tries to understand how a human ...
Brain circuits mediating the orexigenic action of peripheral ghrelin: Narrow gates for a vast kingdom
(Frontiers Research Foundation, 2015-03)
The nervous and endocrine systems act together to regulate all physiological processes essential for the body homeostasis control. Given the strict communication restrictions that the brain-blood barrier (BBB) imposes, the ...
Awakening: Predicting external stimulation to force transitions between different brain states
(National Academy of Sciences, 2019-09)
A fundamental problem in systems neuroscience is how to force a transition from one brain state to another by external driven stimulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases. This requires ...
The conundrum of functional brain networks: Small-world efficiency or fractal modularity
(Frontiers Editorial, 2012-05)
The human brain has been studied at multiple scales, from neurons, circuits, areas with well-defined anatomical and functional boundaries, to large-scale functional networks which mediate coherent cognition. In a recent ...