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Synthesis of 1,5-benzodiazepines with unusual substitution pattern from chalcones under solvent-free microwave irradiation conditions
(2009)
1,5-Benzodiazepines have been synthesized from the corresponding 2'-hydroxychalcones [1-(2-hydroxyphenyl)-3-aryl-2-propen-1-ones] and o-phenylenediamine, both in methanol, under reflux and under solvent-free microwave ...
4-(2-Hydroxyphenyl)-2-phenyl-2,3-dihydro-1H-1,5-benzodiazepine and the 2-(2,3-dimethoxyphenyl)-, 2-(3,4-dimethoxyphenyl)- and 2-(2,5-dimethoxyphenyl)-substituted derivatives
(BLACKWELL PUBLISHING, 2007-07)
The 1,5-benzodiazepine ring system exhibits a puckered boatlike conformation for all four title compounds [4-(2-hydroxyphenyl)2- phenyl-2,3-dihydro-1H-1,5-benzodiazepine, C21H18N2O, (I), 2-(2,3-dimethoxyphenyl)-4-(2-hydr ...
Benzodiazepine use in Chile: Impact of availability on use, abuse, and dependence
(1996)
This study tested the hypothesis whether over-the-counter benzodiazepine availability influenced patterns of benzodiazepine use, abuse, and dependence in Chile. If over-the-counter availability represents a major risk ...
Voltammetric study of 7-nitro-1,4-benzodiazepin-2-ones and their acid hydrolysis products, 2-amino-5-nitrobenzophenones
(1990)
The electrochemical reduction of 7-nitro-1,4-benzodiazepin-2-ones and of their acid hydrolysis products, 2-amino-5-nitrobenzophenones, was studied by polarography and cyclic voltammetry in a solvent - buffer system containing ...
A DFT study of the relationships between electronic structure and peripheral benzodiazepine receptor affinity in a group of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides
(SOC CHILENA QUIMICA, 2010-07-12)
We present here the results of a Density Functional Theory study of the relationships between electronic structure and peripheral benzodiazepine receptor
affinity for a group of N,N-dialkyl-2-phenylindol-3-ylglyoxylamide ...
Benzodiazepines and antidepressants: Effects on cognitive and functional decline in Alzheimer's disease and Lewy body dementia
(International journal of geriatric psychiatry, 2021)
Objectives: We aim to study the effects of the prescription of benzodiazepines and
antidepressants on cognitive and functional decline in older adults living with Alzheimer's disease (AD) and Lewy body dementia (LBD) over ...
( + )-1-(2,5-Dimethoxy+ethylthlophenyl )-2-aminopropane (ALEPH-2), a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors
(Springer, 1996)
Serotonergic behavioral responses, efTects on
motor activity and core temperature, and binding
properties of the novel putative anxiolytic amphe!amine
derivative (± )1-(2,5-dimethoxy-4-ethylthlophenyl)-
2-aminopropane ...
(±)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors
(Springer Verlag, 1996)
Serotonergic behavioral responses, effects on motor activity and core temperature, and binding properties of the novel putative anxiolytic amphetamine derivative (±)1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane ...
Radical Ions of 3-Styryl-quinoxalin-2-one derivatives studied by pulse radiolysis in organic solvents
(Amer Chemical SOC, 2018)
The absorption-spectral and kinetic behaviors of radical ions and neutral hydrogenated radicals of seven 3-styryl-quinoxalin-2(1 H)-one (3-SQ) derivatives, one without substituents in the styryl moiety, four others with ...
Treatment of status epilepticus with midazolam: Four cases TRATAMIENTO DEL ESTADO DE MAL EPILEPTICO CON MIDAZOLAM: PRESENTACION DE 4 CASOS
(1994)
Midazolam is a water-soluble benzodiazepine imide that has been used in recent years to manage status epilepticus (SE). We describe four patients with SE refractory to conventional treatment, whose seizures were controlled ...