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Lipopolysaccharide impairs hepatocyte ureagenesis from ammonia: Involvement of mitochondrial aquaporin-8
(Elsevier, 2014-03)
We recently reported that hepatocyte mitochondrial aquaporin-8 (mtAQP8) channels facilitate the uptake of ammonia and its metabolism into urea. Here we studied the effect of bacterial lipopolysaccharides (LPS) on ammonia-derived ...
Cooperativity in proton sensing by PIP aquaporins
(Wiley Blackwell Publishing, Inc, 2019-03)
One of the most intriguing properties of plasma membrane intrinsic protein (PIP) aquaporins (AQPs) is their ability to modulate water transport by sensing different levels of intracellular pH through the assembly of homo- ...
Further evidence for the involvement of mitochondrial aquaporin-8 in hepatocyte lipid synthesis
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2021-09)
We recently provided evidence suggesting that mitochondrial aquaporin-8 (mtAQP8), a channel protein able to conduct H2O2, is involved in the modulation of hepatocyte cholesterogenesis. To expand that study, we cultured ...
Hypoxia and erythropoietin in the regulation of aquaporins
(Nova Science Publishers, 2020)
Aquaporins (AQPs) constitute a familyof small transmembrane proteins that facilitate osmotically-driven watertransport, and in some cases that of small solutes. Several roles for AQPs havebeen identified, such as the ...
Improved hepatic MRP2/ABCC2 transport activity in LPS-induced cholestasis by aquaporin-1 gene transfer
(Elsevier France-editions Scientifiques Medicales Elsevier, 2019-10)
Multidrug resistance-associated protein 2 (MRP2/ABCC2), a hepatocyte canalicular transporter involved in bile secretion, is downregulated in cholestasis triggered by lipopolysaccharide. The human aquaporin-1 (hAQP1) ...
PIP1 aquaporins: Intrinsic water channels or PIP2 aquaporin modulators?
(Elsevier Science, 2015)
Heteromerization of PIP aquaporins affects their intrinsic permeability
(National Academy of Sciences, 2013-12)
The plant aquaporin plasma membrane intrinsic proteins (PIP) subfamily represents one of the main gateways for water exchange at the plasma membrane (PM). A fraction of this subfamily, known as PIP1, does not reach the PM ...
Aquaporins as targets of dietary bioactive phytocompounds
(Frontiers Media, 2021)