Buscar
Mostrando ítems 41-50 de 636
Assembly, organization and regulation of cell-surface receptors by lectin–glycan complexes
(Portland Press, 2015-06)
Galectins are a family of β-galactoside-binding lectins carrying at least one consensus sequence in the carbohydrate-recognition domain. Properties of glycosylated ligands, such as N- and O-glycan branching, LacNAc ...
Functions of cell surface galectin-glycoprotein lattices
(Elsevier, 2007-10)
Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal ...
Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis
(Elsevier, 2017-01)
Immune checkpoints, a plethora of inhibitory pathways aimed at maintaining immune cell homeostasis, may be co-opted by cancer cells to evade immune destruction. Therapies targeting immune checkpoints have reached a momentum ...
Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate Cancers
(Hindawi Publishing Corporation, 2013-09)
A better understanding of multimolecular interactions involved in tumor dissemination is required to identify new effective therapies for advanced prostate cancer (PCa). Several groups investigated protein-glycan interactions ...
Galectins as modulators of tumour progression
(Nature Publishing Group, 2005-01-01)
Galectins are a family of animal lectins with diverse biological activities. They function both extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and glycolipids, and intracellularly, ...
Delineating the "galectin signature" of the tumor microenvironment
(Landes Bioscience, 2013-04)
Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated 'galectin signature', which delineates the ...
Galectins: Key players in the tumor microenvironment
(Elsevier, 2013)
Galectins are glycan‐binding proteins implicated in several biological activities such as intracellular signaling, cell‐cell communication, cellular proliferation and survival. These endogenous lectins have emerged as key ...
Untangling galectin-driven regulatory circuits in autoimmune inflammation
(Elsevier, 2018-04)
Although significant progress has been made in understanding the mechanisms implicated in the pathogenesis and resolution of autoimmune inflammation, studies aimed at identifying mediators of these pathways are necessary ...
The Role of Galectin-3 and ST2 in Cardiology: A Short Review
(Molecular Diversity Preservation International, 2021-08)
Galectin-3 is a lectin that binds beta-galactosides. It is involved in cardiac remodeling and fibrosis through the activation of macrophages and fibroblasts. ST2 is secreted by myocardial cells due to cardiac overload. ...
Absence of galectin-3 does not affect the development of experimental tongue carcinomas in mice
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)
Background: Galectin-3 is a lectin that presents pivotal roles in tumor biology and there are no studies evaluating their expression in dysplasias and carcinomas developed from tongue carcinogenesis models. Aims: To ...