Artículos de revistas
Galectins as modulators of tumour progression
Fecha
2005-01-01Registro en:
Liu, Fu Tong; Rabinovich, Gabriel Adrián; Galectins as modulators of tumour progression; Nature Publishing Group; Nature Reviews Cancer; 5; 1; 1-1-2005; 29-41
1474-175X
1474-1768
CONICET Digital
CONICET
Autor
Liu, Fu Tong
Rabinovich, Gabriel Adrián
Resumen
Galectins are a family of animal lectins with diverse biological activities. They function both extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and glycolipids, and intracellularly, by interacting with cytoplasmic and nuclear proteins to modulate signalling pathways. Current research indicates that galectins have important roles in cancer; they contribute to neoplastic transformation, tumour cell survival, angiogenesis and tumour metastasis. They can modulate the immune and inflammatory responses and might have a key role helping tumours to escape immune surveillance. How do the different members of the Galectin family contribute to these diverse aspects of tumour biology?