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Synthesis and thermal study of the prodrug of oxamniquine
(Springer, 2014)
Synthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approaches
(Molecular Diversity Preservation Int, 2008-04-01)
We report the synthesis and total NMR characterization of 5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid-3-[[[(4″- nitrophenoxy)carbonyl]oxy]-methyl]-8-oxo-7-[(2-thienyloxoacetyl)amino] -diphenylmethyl ester-5-dioxide ...
Synthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approaches
(Molecular Diversity Preservation Int, 2014)
In vitro and in vivo evaluation of a primaquine prodrug without red blood cell membrane destabilization property
(Wiley-Blackwell, 2012-11-01)
Primaquine is an important therapeutic resource for malaria treatment and it has wide activity against several pathogens. The haematotoxicity of primaquine is the major problem for its therapeutic application. This effect ...
In vitro and in vivo evaluation of a primaquine prodrug without red blood cell membrane destabilization property
(Wiley-Blackwell, 2012-11-01)
Primaquine is an important therapeutic resource for malaria treatment and it has wide activity against several pathogens. The haematotoxicity of primaquine is the major problem for its therapeutic application. This effect ...
Prodrugs for the treatment of neglected diseases
(Molecular Diversity Preservation Int, 2008-03-01)
Recently, World Health Organization ( WHO) and Medicins San Frontieres (MSF) proposed a classification of diseases as global, neglected and extremely neglected. Global diseases, such as cancer, cardiovascular and mental ...
Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug
(Wiley-Blackwell, 2006-06-01)
Pyrazinamide was condensed with the poly(ethylene glycol)-poly(aspartic acid) copolymer (PEG-PASP), a micelle-forming derivative was obtained that was characterized in terms of its critical micelle concentration (CMC) and ...
Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug
(Wiley-Blackwell, 2006-06-01)
Pyrazinamide was condensed with the poly(ethylene glycol)-poly(aspartic acid) copolymer (PEG-PASP), a micelle-forming derivative was obtained that was characterized in terms of its critical micelle concentration (CMC) and ...
Stability and plasmatic protein binding of novel zidovudine prodrugs: Targeting site ii of human serum albumin
(Elsevier Science, 2018-03)
Despite its vastly demonstrated clinical efficacy, zidovudine (AZT) exhibits several suboptimal pharmacokinetic properties. In particular, its short plasmatic half-life (t1/2 ~ 1 h) is related to its low bound fraction to ...