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Insertion/deletion polymorphism of the bradykinin type 2 receptor gene influence diastolic blood pressure
(NATURE PUBLISHING GROUP, 2009)
The contribution of kinins to the beneficial effects in cardiovascular risk reductions remains unclear. In this context, the present study examined whether the +9bp/-9 bp polymorphism in bradykinin type 2 receptor gene, ...
Assessing Interethnic Admixture Using an X-Linked Insertion-Deletion Multiplex
(WILEY-LISS, 2009)
In this study, a PCR multiplex was optimized, allowing the simultaneous analysis of 13 X-chromosome Insertion/deletion polymorphisms (INDELs). Genetic variation observed in Africans, Europeans, and Native Americans reveals ...
Identification and characterization of a novel large insertion/deletion polymorphism of 1464 base pair in the human thyroglobulin gene
(Mary Ann Liebert, 2003-04)
We identified a novel large insertion/deletion (Indel) polymorphism of 1464 bp localized in intron 18 of the human thyroglobulin gene. Data from sequence showed a high A+T content (62%), two 17-bp long motif repeats, and ...
Next-Generation Sequencing Reveals Pathway Activations and New Routes to Targeted Therapies in Cutaneous Metastatic Melanoma
(Lippincott Williams & Wilkins, 2017-01-01)
Background: Comprehensive genomic profiling of clinical samples by next-generation sequencing (NGS) can identify one or more therapy targets for the treatment of metastatic melanoma (MM) with a single diagnostic test. ...
Machine learning reveals a non‐canonical mode of peptide binding to MHC class II molecules
(Wiley Blackwell Publishing, Inc, 2017-10)
MHC class II molecules play a fundamental role in the cellular immune system: they load short peptide fragments derived from extracellular proteins and present them on the cell surface. It is currently thought that the ...
CREditing: a tool for gene tuning in Trypanosoma cruzi
(Elsevier, 2023)
A rapid detection method for PAI-1 promoter insertion/deletion polymorphism (4G/5G)
(Sociedade Brasileira de Genética, 1998)