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Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain
(Elsevier B.V., 2007-03-02)
Chronic exposure to Cannabis sativa (marijuana) produced a significant down-regulation of cannabinoid receptor in the postmortem human brain. the significant decrease in maximal binding capacity was not accompanied by ...
GABAA Receptor Binding and Ion Channel Function in Primary Neuronal Cultures for Neuropharmacology/Neurotoxicity Testing
(Humana Press, 2011)
GABAA receptor (GABAAR) constitutes the main inhibitory receptor of the central nervous system. Due to the wide distribution and activity of its main neurotransmitter agonist, the γ-aminobutyric acid (GABA), its pharmacology ...
The Effect of Endogenous Modulator Endobain E on NMDA Receptor Is Interfered by Zn 2+ but Is Independent of Modulation by Spermidine
(Springer/Plenum Publishers, 2004-04)
A brain endogenous factor, termed endobain E, allosterically decreases [ 3H]dizocilpine binding to NMDA receptor. Such effect depends on receptor activation by the coagonists glutamate and glycine and is interfered by ...
Molecular basis of ligand dissociation in β-adrenergic receptors
(Public Library of Science, 2011)
The important and diverse biological functions of β-adrenergic receptors (βARs) have promoted the search for compounds to stimulate or inhibit their activity. In this regard, unraveling the molecular basis of ligand ...
Reinforcing properties of fencamfamine: Involvement of dopamine and opioid receptors
(1995-01-17)
Fencamfamine (FCF) is a psychostimulant classified as an indirect dopamine agonist. The conditioning place preference (CPP) paradigm was used to investigate the reinforcing properties of FCF. After initial preferences had ...
Reinforcing properties of fencamfamine: Involvement of dopamine and opioid receptors
(1995-01-17)
Fencamfamine (FCF) is a psychostimulant classified as an indirect dopamine agonist. The conditioning place preference (CPP) paradigm was used to investigate the reinforcing properties of FCF. After initial preferences had ...
Allosterically linked noncompetitive antagonist binding sites in the resting nicotinic acetylcholine receptor ion channel
(Elsevier Science Inc, 2002-07-01)
Previous studies have established the presence of overlapping binding sites for the noncompetitive antagonists (NCAs) amobarbital, tetracaine, and 3-trifluoromethyl-3-(m-[ 125 I]iodophenyl) diazirine ([ 125 I]TID) within ...
Elimination of erroneous results related to bovine mononuclear cell immunophenotyping by antibodies binding to Fc receptors
(Elsevier B.V., 2019-07-01)
Blocking immunoglobulin G (IgG) binding receptors on leukocytes is an established and highly recommended preventive procedure for immunological assays. Failing to prevent such nonspecific binding can lead to erroneous ...