Artigo
Reinforcing properties of fencamfamine: Involvement of dopamine and opioid receptors
Date
1995-01-17Registration in:
Pharmacology Biochemistry and Behavior, v. 50, n. 1, p. 35-40, 1995.
0091-3057
10.1016/0091-3057(94)00236-C
WOS:A1995QA54700006
2-s2.0-0028799567
2514762545280942
0000-0002-1378-6327
Author
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Abstract
Fencamfamine (FCF) is a psychostimulant classified as an indirect dopamine agonist. The conditioning place preference (CPP) paradigm was used to investigate the reinforcing properties of FCF. After initial preferences had been determined, animals were conditioned with FCF (1.75, 3.5, or 7.0 mg/kg; IP). Only at the dose of 3.5 mg/kg FCF produced a significant place preference. Pretreatment with SCH23390 (0.05 mg/kg, SC) or naloxone (1.0 mg/kg SC) 10 min before FCF (3.5 mg/kg; IP) blocked both FCF-induced hyperactivity and CPP. Pretreatment with metoclopramide (10.0 mg/kg; IP) or pimozide (1.0 mg/kg, IP), respectively, 30 min or 4 h before FCF (3.5 mg/kg; IP), which blocked the FCF-induced locomotor activity, failed to influence place conditioning produced by FCF. In conclusion, the present study suggests that dopamine D 1 and opioid receptors are related to FCF reinforcing effect, while dopamine D 2 subtype receptor was ineffective in modifying FCF-induced CPP.
Subjects
Related items
Showing items related by title, author, creator and subject.
-
Dopamine D 4 receptor, but not the ADHD-associated D 4.7 variant, forms functional heteromers with the dopamine D 2S receptor in the brain
González, S.; Rangel Barajas, C.; Peper, Marcela; Lorenzo Lopez, Juan Ramiro; Moreno, E.; Ciruela, F.; Borycz, J.; Ortiz, J.; Lluís, C.; Franco, R.; McCormick, P. J.; Volkow, N. D.; Rubinstein, Marcelo; Floran, B.; Ferré, S. (Nature Publishing Group, 2012-06)Polymorphic variants of the dopamine D 4 receptor have been consistently associated with attention-deficit hyperactivity disorder (ADHD). However, the functional significance of the risk polymorphism (variable number of ... -
Enhanced expression of dopamine D1 and glutamate NMDA receptors in dopamine D4 receptor knockout mice
Gan, Lu; Falzone, Tomas Luis; Zhang, Kehong; Rubinstein, Marcelo; Baldessarini, Ross J.; Tarazi, Frank I. -
Expression analysis of dopamine receptor subtypes in normal human pituitaries, nonfunctioning pituitary adenomas and somatotropinomas, and the association between dopamine and somatostatin receptors with clinical response to octreotide-LAR in acromegaly
Vieira Neto, Leonardo; Machado, Evelyn de O.; Luque, Raul M.; Taboada, Giselle F.; Marcondes, Jorge B.; Chimelli, Leila M. C.; Quintella, Leonardo Pereira; Niemeyer Jr., Paulo; Carvalho, Denise P. de; Kineman, Rhonda D.; Gadelha, Mônica R. (Oxford University Press, 2009)