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Role of Trypanosoma cruzi nucleoside diphosphate kinase 1 in DNA damage responses
(Fundação Oswaldo Cruz, 2020-07)
BACKGROUND NME23/NDPKs are well conserved proteins found in all living organisms. In addition to being nucleoside diphosphate kinases (NDPK), they are multifunctional enzymes involved in different processes such as DNA ...
A novel stage-specific glycosomal nucleoside diphosphate kinase from Trypanosoma cruzi
(Czech Academy of Sciences. Institute of Parasitology, 2017-02)
Nucleoside diphosphate kinases (NDPK) are key enzymes involved in the intracellular nucleotide maintenance in all living organisms, especially in trypanosomatids which are unable to synthesise purines de novo. Four putative ...
Caracterización bioquímica y molecular de nucleósido difosfato quinasas de Solanum tuberosum (StNDPKs): análisis de su expresión en la planta de papa en respuesta a estresesBiochemical and molecular characterization of nucleoside diphosphate kinase from Solanum tuberosum (StNDPKs): analysis of its expression in the potato plant in response to stress
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2012)
Trypanosoma cruzi: Multiple nucleoside diphosphate kinase isoforms in a single cell
(Academic Press Inc Elsevier Science, 2008-09)
Nucleoside diphosphate kinases (NDPKs) are multifunctional enzymes involved mainly in the conservation of nucleotides and deoxynucleotides at intracellular levels. Here we report the characterization of two NDPKs from the ...
Cytosolic Trypanosoma cruzi nucleoside diphosphate kinase generates large granules that depend on its quaternary structure
(Academic Press Inc Elsevier Science, 2014-07)
Nucleoside diphosphate kinase (NDPK) is a key enzyme in the control of cellular concentrations of nucleoside triphosphates, and has been shown to play important roles in many cellular processes. In this work we investigated ...
Structural and kinetic studies of Schistosoma mansoni adenylate kinases
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
The human parasite Schistosoma mansoni is totally dependent on the purine salvage pathway in order to supply large quantities of purine precursors for its energy and DNA biosynthetic needs. Adenylate kinase (ADK) is ...
Revisiting trypanosomatid nucleoside diphosphate kinases
(Fundação Oswaldo Cruz, 2021-12)
Background: An increasing amount of research has led to the positioning of nucleoside diphosphate kinases (NDPK/NDK) as key metabolic enzymes among all organisms. They contribute to the maintenance the intracellular di- ...
Protein preparation, crystallization and preliminary X-ray analysis of Trypanosoma cruzi nucleoside diphosphate kinase 1
(WILEY-BLACKWELL PUBLISHING, INC, 2010)
The flagellated protozoan parasite Trypanosoma cruzi is the aetiological agent of Chagas disease. Nucleoside diphosphate kinases (NDPKs) are enzymes that are involved in energy management and nucleoside balance in the cell. ...
Determinação da reatividade diferencial de anticorpos de bovinos vacinados com a cepa S19 de Brucella abortus e naturalmente infectados através de análises imunoproteômicas
(Universidade Federal de UberlândiaBRPrograma de Pós-graduação em Imunologia e Parasitologia AplicadasCiências BiológicasUFU, 2016)