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Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia
(Frontiers Media, 2020)
Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such ...
Desaturation and heme elevation during COVID-19 infection: a potential prognostic factor of heme oxygenase-1
Increased heme levels, anemia, and desaturation occur during infection. We aimed to
compare the levels of heme, heme oxygenase-1 (HO-1), ferritin, and bilirubin in coronavirus
disease 2019 (COVID-19) patients at different ...
Heme-iron utilization by Leptospira interrogans requires a heme oxygenase and a plastidic-type ferredoxin-NADP+ reductase
(Elsevier Science, 2014-07)
Background: Heme oxygenase catalyzes the conversion of heme to iron, carbon monoxide and biliverdin employing oxygen and reducing equivalents. This enzyme is essential for heme-iron utilization and contributes to virulence ...
Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells
(Public Library of Science, 2018)
Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction
(Elsevier B.V., 2005-02-15)
Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that acts during inflammatory reactions as the rate-limiting step in the catabolism of heme, yielding equimolar amounts of iron (Fe), biliverdin, and the gas carbon ...
Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury
(BaishidengBeijing, 2013-10-27)
The activation of heme oxygenase-1 (HO-1) appears to be an endogenous defensive mechanism used by cells to reduce inflammation and tissue damage in a number of injury models. HO-1, a stress-responsive enzyme that catabolizes ...
Immune modulation by inhibitors of the HO system
(MDPI AG, 2021-01)
The heme oxygenase (HO) system involves three isoforms of this enzyme, HO-1, HO-2, and HO-3. The three of them display the same catalytic activity, oxidating the heme group to produce biliverdin, ferrous iron, and carbon ...
Pharmacological Induction of Heme Oxygenase-1 Activity Blocks Herpes Simplex Virus Infection
(2017)
Heme oxygenase-1 (HO-1) is a host inducible enzyme that responds to numerous stress-related stimuli, such as reactive oxygen species, hyperthermia,
UV radiation and infections. HO-1 degrades iron-containing heme into ferrous ...
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases
(Frontiers Media S.A., 2020-07)
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. ...
Immunoregulatory Properties of Heme Oxygenase-1
(2011)
Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. HO-1 is induced by its substrate and by ...