Pharmacological Induction of Heme Oxygenase-1 Activity Blocks Herpes Simplex Virus Infection

Abstract

Heme oxygenase-1 (HO-1) is a host inducible enzyme that responds to numerous stress-related stimuli, such as reactive oxygen species, hyperthermia, UV radiation and infections. HO-1 degrades iron-containing heme into ferrous iron (Fe2+), carbon monoxide (