capítulo de libro
Immunoregulatory Properties of Heme Oxygenase-1
Fecha
2011Registro en:
10.1007/978-1-60761-869-0_18
Autor
Blancou, Philippe
Tardif, Virginie
Simon, Thomas
Rémy, Séverine
Carreño, Leandro
Kalergis, Alexis M.
Anegon, Ignacio
Institución
Resumen
Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. HO-1 is induced by its substrate and by other stimuli, including agents involved in oxidative stress and proinflammatory cytokines as well as several anti-inflammatory stimuli. A growing body of evidence points toward the capacity of this molecule to inhibit immune reactions and the pivotal role of HO-1 in inflammatory diseases. We will first review the physiological role of HO-1 as determined by the analysis of HO-1-deficient individuals. This will be followed by an examination of the effect of HO-1 within immunopathological contexts such as immune disorders (autoimmunity and allergy) or infections. A section will be devoted to the use of an HO-1 inducer as an immunosuppressive molecule in transplantation. Finally, we will review the molecular basis of HO-1 actions on different immune cells.