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A potential role for a novel ZC3H5 complex in regulating mRNA translation in Trypanosoma brucei
(American Society for Biochemistry and Molecular Biology, 2020-08)
In Trypanosoma brucei and related kinetoplastids, gene expression regulation occurs mostly post-transcriptionally. Consequently, RNA-binding proteins play a critical role in the regulation of mRNA and protein abundance. ...
Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K + currents in adult murine atria
(American Physiological Society, 2018-05)
G protein-gated inwardly rectifying K+ (GIRK) channels are the major inwardly rectifying K+ currents in cardiac atrial myocytes and an important determinant of atrial electrophysiology. Inhibitory G protein α-subunits can ...
Human MageB2 protein expression enhances E2F transcriptional activity, cell proliferation, and resistance to ribotoxic stress
(American Society for Biochemistry and Molecular Biology, 2015-12)
MageB2 belongs to the melanoma antigen gene (MAGE-I) family of tumor-specific antigens. Expression of this gene has been detected in human tumors of different origins. However, little is known about the protein function ...
The small secreted effector protein MiSSP7.6 of Laccaria bicolor is required for the establishment of ectomycorrhizal symbiosis
(Wiley Blackwell Publishing, Inc, 2020-04)
To establish and maintain a symbiotic relationship, the ectomycorrhizal fungus Laccaria bicolor releases mycorrhiza-induced small secreted proteins (MiSSPs) into host roots. Here, we have functionally characterized the ...
Functional interaction between co-expressed MAGE-A proteins
(Public Library of Science, 2017-05)
MAGE-A (Melanoma Antigen Genes-A) are tumor-associated proteins with expression in a broad spectrum of human tumors and normal germ cells. MAGE-A gene expression and function are being increasingly investigated to better ...
Expression of plant receptor kinases in yeast
(Springer, 2017)
The budding yeast Saccharomyces cerevisiae is a useful system to express recombinant proteins and analyze protein?protein interaction. Membrane-spanning proteins like plant receptor kinases find their way to the plasma ...
Translational repression by an RNA-binding protein promotes differentiation to infective forms in Trypanosoma cruzi
(Public Library of Science, 2018-06)
Trypanosomes, protozoan parasites of medical importance, essentially rely on post-transcriptional mechanisms to regulate gene expression in insect vectors and vertebrate hosts. RNA binding proteins (RBPs) that associate ...
Regulation of placental leptin expression by cyclic adenosine 5′-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways
(Endocrine Society, 2010-08)
Leptin, a 16-kDa protein mainly produced by adipose tissue, has been involved in the control of energy balance through its hypothalamic receptor. However, pleiotropic effects of leptin have been identified in reproduction ...
Small stress proteins, biomarkers of cancer
(Nova Science Publishers, 2010)
Many oncogenic agents/events generate in cancer cells stress-responsive proteins, also known as heat shock proteins (HSPs). These proteins are implicated in the genesis as well as in the progression of cancer; the small ...