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Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease
(Pergamon-Elsevier Science Ltd, 2018-12)
The natural history of preclinical late-onset Alzheimer's disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of AD. With the ...
Pharmacology and toxicology of polyphenols with potential as neurotropic agents in non-communicable diseases
(Bentham Science Publishers, 2018-03)
The central nervous system (CNS) is involved in organic integration. Nervousmodulation via bioactive compounds can modify metabolism in order to prevent systemic noncommunicablediseases (NCDs). Concerning this, plant ...
In Vivo Studies of Protein Misfolding and Neurodegeneration Induced by Metabolic Syndrome Relative to Chronic Cerebral Hypoperfusion: A Critical Review
(IntechOpen, 2020)
Metabolic syndrome (MetS) leads to microvascular dysfunction and chronic cerebral hypoperfusion (CCH) in an insidious way. Clinical evidence and several rodent models have contributed to determining the neurodegenerative ...
Trypanothione metabolism as drug target for trypanosomatids
(Bentham Science Publishers, 2020-09)
Chagas Disease, African sleeping sickness, and leishmaniasis are neglected diseases caused by pathogenic trypanosomatid parasites, which have a considerable impact on morbidity and mortality in poor countries. The available ...
Nonalcoholic fatty liver disease associated with metabolic syndrome: Influence of liver fibrosis stages on characteristics of very low-density lipoproteins
(Elsevier Science, 2017-10)
Background We evaluated possible changes in VLDLcharacteristics, and metabolic related factors, in MetS-associated NAFLD and accompanying liver fibrosis. Methods We studied 36 MetS patients with biopsy-proven NAFLD (MetS ...
Neuroendocrine-metabolic dysfunction and sleep disturbances in neurodegenerative disorders: Focus on Alzheimer's disease and melatonin
(Karger, 2018-10)
Alzheimer's disease (AD) is associated with altered eating behavior and metabolic disruption. Amyloid plaques and neurofilament tangles are observed in many hypothalamic nuclei from AD brains. Some of these areas ...
Identification of N-benzylacetamide as a major component of human plasmatic metabolic profiling of benznidazole
(Medecine Et Hygiene, 2014-04)
Chagas disease is an endemic infection in Latin America with a high health impact. Caused by the parasite Trypanosoma cruzi, it has expanded to non-endemic regions such as North America and European countries via immigration ...
Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences
(De Gruyter, 2014-05)
Background: A substantial body of epidemiological and experimental evidence suggests that a poor fetal and neonatal environment may "program" susceptibility in the offspring to later development of cardiovascular, renal ...
Intrauterine programming of adult disease: Identification of cardinal genes associated with hypertension, obesity and metabolic syndromeProgramación intrauterina de enfermedad en la vida adulta: Identificación de genes cardinales asociados a hipertensión arterial, obesidad y síndrome metabólico
(Sociedad Argentina de Cardiologia, 2021-04)
Introducción: La restricción del crecimiento intrauterino es una alteración del desarrollo fetal que se caracteriza por una tasa de crecimiento durante la etapa fetal que es menor al potencial genético de crecimiento para ...
The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies
(Bentham Science Publishers, 2018-09)
Chagas´ disease continues to be a challenging and neglected public health problem in many American countries. The etiologic agent, Trypanosoma cruzi, develops intracellularly in the mammalian host, which hinders treatment ...