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Machine learning reveals a non‐canonical mode of peptide binding to MHC class II molecules
(Wiley Blackwell Publishing, Inc, 2017-10)
MHC class II molecules play a fundamental role in the cellular immune system: they load short peptide fragments derived from extracellular proteins and present them on the cell surface. It is currently thought that the ...
Phage-Display-Derived Peptide Binds to Human CD206 and Modeling Reveals a New Binding Site on the Receptor
(American Chemical Society, 2019-03)
We recently identified a tumor-homing peptide (mUNO, sequence: "CSPGAK") that specifically interacts with mouse CD206 to target CD206/MRC1-expressing tumor-associated macrophages in mice. Here, we report studies on the ...
An inhibitory mechanism of action of coiled-coil peptides against type three secretion system from enteropathogenic Escherichia coli
(John Wiley & Sons Ltd, 2019-03)
Human pathogenic gram-negative bacteria, such as enteropathogenic Escherichia coli (EPEC), rely on type III secretion systems (T3SS) to translocate virulence factors directly into host cells. The coiled-coil domains present ...
A Systematic, Unbiased Mapping of CD8+ and CD4+ T Cell Epitopes in Yellow Fever Vaccinees
(Frontiers Media S.A., 2020-08)
Examining CD8+ and CD4+ T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8+ and 50 CD4+ T cell epitopes, many inducing strong and prevalent ...
An inhibitory mechanism of action of coiled‐coil peptides against type three secretion system from enteropathogenic Escherichia coli
(Wiley, 2019-03)
Human pathogenic gram‐negative bacteria, such as enteropathogenic Escherichia coli (EPEC), rely on type III secretion systems (T3SS) to translocate virulence factors directly into host cells. The coiled‐coil domains present ...
Anti-tumoral Effect of a Cell Penetrating and Interfering Peptide Targeting PP2A/SET InteractionПротивоопухолевый эффект клеточнопроникающего и интерферирующего пептида, нацеленного на взаимодействие PP2A / SET
(National Library of Medicine's (Medline), 2020-03)
OBJECTIVE: To test cell penetrating and interfering peptide Mut3DPT-PP2A/SET in interaction between serine threonine phosphatase PP2A and its physiological inhibitor, the oncoprotein SET. MATERIALS AND METHODS: Adult male ...
Multicomponent venom of the spider Cupiennius salei: A bioanalytical investigation applying different strategies
(Wiley Blackwell Publishing, Inc, 2012-08)
The multicomponent venom of the spider Cupiennius salei was separated by three different chromatographic strategies to facilitate subsequent analysis of peptidic venom components by tandem mass spectrometry (MALDI‐TOF‐MS ...
Pseudomonas fluorescens Pf-5 genome-wide mutant screen for resistance to the antimicrobial peptide alfalfa snakin-1
(Oxford University Press, 2015-01)
Snakin-1, a peptide produced by higher plants, has broad-spectrum antibiotic activity, inhibiting organisms ranging from Bacteria to Eukaryotes. However, the mode of action against target organisms is poorly understood. ...
Structural conformation and self‐assembly process of p31‐43 gliadin peptide in aqueous solution. Implications for celiac disease
(Wiley Blackwell Publishing, Inc, 2019-10)
Celiac Disease (CeD) is a highly prevalent chronic immune-mediated enteropathy developed in genetically predisposed individuals after ingestion of a group of wheat proteins (called gliadins and glutenins). The 13mer α-gliadin ...