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Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows
(Humana Press, 2017)
We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, ...
Fitness of drug resistant Mycobacterium tuberculosis and the impact on the transmission among household contacts
(Elsevier, 2014-12)
There has been an on-going debate on whether the development of drug resistance in Mycobacterium tuberculosis reduces its relative fitness and its ability to cause disease. The aim of this study was to explore this ...
Effect of the metabolic inhibitor, methimazole on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica
(Cambridge University Press, 2009-02)
A study has been carried out to investigate whether the action of triclabendazole (TCBZ) is altered in the presence of a metabolic inhibitor. The flavin monooxygenase system (FMO) was inhibited using methimazole (MTZ) to ...
Fitness of drug resistant Mycobacterium tuberculosis and the impact on the transmission among household contacts
(Churchill Livingstone, 2014)
Surveillance and Characterization of Drug‑Resistant Mycobacterium tuberculosis Isolated in a Reference Hospital from Argentina during 8 Years’ Period
(Wolters Kluwer, 2019-09)
Background: Argentina is considered a country with a middle tuberculosis (TB) incidence. However, according to the last national epidemiological report released in 2018, since 2013, the trends are steadily increasing. The ...
Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health
(American Society of Tropical Medicine and Hygiene, 2008-11)
Multidrug-resistant Plasmodium falciparum malaria is a severe public health problem on the Thailand-Myanmar border. Many villagers buy packets of 4-5 mixed medicines ("yaa chud") from shops without medical assessment as ...
Evaluation of Mycobacterium tuberculosis cross-resistance to isoniazid, rifampicin and levofloxacin with their respective structural analogs
(Nature Publishing Group, 2014-11)
The emergence of drug-resistant, multidrug-resistant and extensively drug-resistant tuberculosis (TB) is of major public health concern in several countries. In this study, the pharmacodynamic relationships among the ...
A life with seizures: Argentine patients’ perspectives about the impact of drug-resistant epilepsy on their lives
(Elsevier, 2018-12)
Purpose: To understand the experience of drug-resistant epilepsy in patients from Argentina, a developing nation. Method: A qualitative approach using semi-structured interviews was used to gain an in-depth and contextual ...
Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance
(Elsevier Science, 2011-08)
A mathematical modeling of controlled release of drug from one-layer and two-layer torus-shaped devices with external mass transfer resistance is presented. Analytical solutions based on the pseudosteady state approximation ...
Surveillance and characterization of drug‑resistant mycobacterium tuberculosis isolated in a reference hospital from Argentina during 8 years’ period
(Wolters Kluwer, 2019-09)
Background: Argentina is considered a country with a middle tuberculosis (TB) incidence. However, according to the last national epidemiological report released in 2018, since 2013, the trends are steadily increasing. The ...