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ATP modulation of mitogen activated protein kinases and intracellular Ca2+ in breast cancer (MCF-7) cells
(Elsevier Science Inc, 2007-10-01)
In the breast tumor cell line MCF-7, extracellular nucleotides induce transient elevations in intracellular calcium concentration ([Ca2+]i). In this study we show that stimulation with ATP or UTP sensitizes MCF-7 cells to ...
Extracellular vesicles released upon stimulation with antiphospholipid antibodies : An actual direct procoagulant mechanism or a new factor in the lupus anticoagulant paradox?
(ElsevierGrupo de Investigación en TrombosisGrupo ReproducciónLondres, Inglaterra, 2022)
Pharmocologic inhibitors of the mitogen activated protein kinase cascade have the potential to interact with ionizing radiation exposure to induce cell death in carcinoma cells by multiple mechanisms
(Taylor & Francis, 2002-12)
Recent studies have shown that inhibition of stress-induced signaling via the mitogen activated protein kinase (MAPK) pathway can potentiate the toxic effects of chemotherapeutic drugs and ionizing radiation. Because of ...
MAP kinases p38 and JNK are activated by the steroid hormone 1α,25(OH)2-vitamin D3 in the C2C12 muscle cell line
(Wiley-liss, Div John Wiley & Sons Inc, 2006-03-07)
In chick skeletal muscle cell primary cultures, we previously demonstrated that 1α,25(OH)2-vitamin D3 [1α,25(OH) 2D3], the hormonally active form of vitamin D, increases the phosphorylation and activity of the extracellular ...
The action of the mast cell product tryptase on cyclooxygenase-2 (COX2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2)
(Elsevier Science Inc, 2005-04)
The mast cell product tryptase, via protease-activated receptor 2 (PAR2), induces cyclooxygenase-2 (COX2) and 15-deoxy-prostaglandin J2 (15d-PGJ2) synthesis. 15d-PGJ2, through the nuclear peroxisome proliferator activated ...
Brucella abortus induces TNF-á-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases
(Biomed Central Ltd, 2013-04)
Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. We have recently demonstrated that B. abortus infects microglia and astrocytes, eliciting ...
Atypical protein kinase C-ζ modulates clonogenicity, motility, and secretion of proteolytic enzymes in murine mammary cells
(Wiley-liss, div John Wiley & Sons Inc., 2005-01)
In this paper, we investigated whether protein kinase C-ζ (PKCζ), a member of the atypical PKC family, induces phenotypic alterations associated with malignant transformation and tumor progression in mammary cells. The ...