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Genetic identification and drug-resistance characterization of mycobacterium tuberculosis using a portable sequencing device. A pilot study
(MDPI AG, 2020-09)
Clinical management of tuberculosis (TB) in endemic areas is often challenged by a lack of resources including laboratories for Mycobacterium tuberculosis (Mtb) culture. Traditional phenotypic drug susceptibility testing ...
Rational Pharmacotherapy in Infectious Diseases: Issues Related to Drug Residues in Edible Animal Tissues
(Multidisciplinary Digital Publishing Institute, 2021-10)
Drugs are used in veterinary medicine to prevent or treat animal diseases. When rationally administered to livestock following Good Veterinary Practices (GVP), they greatly contribute to improving the production of food ...
Anthelmintic therapy in ruminant species: Understanding of the host-drug-parasite interaction
(Bentham Science Publishers, 2010-05)
Inadequate use of anthelmitic drugs in livestock animals has led to therapeutic failures and to the dramatic widespread development of parasite resistance. Additional scientific knowledge on how to improve the use of ...
Is cannabidiol a drug acting on unconventional targets to control drug-resistant epilepsy
(Wiley Blackwell Publishing, Inc, 2020-01)
Cannabis has been considered as a therapeutic strategy to control intractable epilepsy. Several cannabis components, especially cannabidiol (CBD), induce antiseizure effects. However, additional information is necessary ...
Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression
(Pergamon-Elsevier Science Ltd, 2019-01)
Acyl-CoA synthetase-4 (ACSL4) is an enzyme implicated in estrogen receptor α (ERα) negative regulation and hormone therapy resistance in breast cancer. In addition, ACSL4 has been associated to certain types of hormone ...
String test: A new tool for tuberculosis diagnosis and drug-resistance detection in children
(Wolters Kluwer Medknow Publications, 2018-04)
Background: There is a critical need to improve the diagnostic accuracy of tuberculosis (TB) in children. Several techniques have been developed to improve the quality of sputum samples; however, these procedures are very ...
Drug resistance in parasitic helminths of veterinary importance in Chile: status review and research needsDrug resistance in parasitic helminths of veterinary importance in Chile: status review and research needs
(Faculty of Veterinary Sciences - Universidad Austral de Chile, 2018)
Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender and age issues
(Mary Ann Liebert Inc, 2011-12)
We studied drug resistance mutations (DRMs) in 2623 pol sequences. Out of 94,828 amino acid substitutions that were detected, 8749 corresponded to nucleoside reverse transcriptase inhibitor (NRTI), 3765 to nonnucleoside ...
Strategies to Optimize the Efficacy of Anthelmintic Drugs in Ruminants
(Elsevier, 2018-08)
Anthelmintic resistance in human and animal pathogenic helminths has been spreading in prevalence and severity. Multidrug resistance is a widespread problem in livestock animals. The use of available pharmacology-based ...