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Mostrando ítems 131-140 de 149
Galectin-1-driven tolerogenic programs aggravate Yersinia enterocolitica infection by repressing antibacterial immunity
(American Association of Immunologists, 2017-08)
Yersinia enterocolitica is an enteropathogenic bacterium that causes gastrointestinal disorders, as well as extraintestinal manifestations. To subvert the host's immune response, Y. enterocolitica uses a type III secretion ...
Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy
(Oxford University Press, 2013-01)
Galectin-1 (gal-1) is expressed at the feto-maternal interface and plays a role in regulating the maternal immune response against placental alloantigens, contributing to pregnancy maintenance. Both decidua and placenta ...
Regeneración axonal posterior a lesiones traumáticas de médula espinal: papel crítico de galectina-1Axonal regeneration in spinal cord injury: a key role of galectin-1
(Medicina (Buenos Aires), 2014-05)
Al producirse una lesión de médula espinal (LME), un sinnúmero de proteínas inhibidoras de la regeneración axonal ocupan el sitio de lesión en forma secuencial. La primer proteína en llegar al mismo se conoce como semaforina ...
Placental glycoredox dysregulation associated with disease progression in an animal model of superimposed preeclampsia
(MDPI AG, 2021-04)
Pregnancies carried by women with chronic hypertension are at increased risk of superimposed preeclampsia, but the placental pathways involved in disease progression remain poorly understood. In this study, we used the ...
Carbohydrate-binding proteins: dissecting ligand structures through solvent environment occupancy
(American Chemical Society, 2009-06)
Formation of protein ligand complexes is a fundamental phenomenon in biochemistry. During the process, significant solvent reorganization is produced along the contact surface and many water molecules strongly bound to the ...
Decay-Accelerating Factor 1 Deficiency Exacerbates Leptospiral-Induced Murine Chronic Nephritis and Renal Fibrosis
(Public Library of Science, 2014-07)
Leptospirosis is a global zoonosis caused by pathogenicLeptospira, which can colonize the proximal renal tubules andpersist for long periods in the kidneys of infected hosts. Here, we characterized the infection of C57BL/6J ...
Glycobiology of immune responses
(John Wiley & Sons Inc, 2012-04-23)
Unlike their protein roommates and their nucleic acid cousins, carbohydrates remain an enigmatic arm of biology. The central reason for the difficulty in fully understanding how carbohydrate structure and biological function ...
Bacterial glycans and their interactions with lectins in the innate immune system
(Journal of the Serbian Chemical Society, 2019-11)
Bacterial surfaces are rich in glycoconjugates that are mainly present in their outer layers and are of great importance for their interaction with the host innate immune system. The innate immune system is the first barrier ...
Altered Glycosylation Contributes to Placental Dysfunction Upon Early Disruption of the NK Cell-DC Dynamics
(Frontiers Media, 2020-07)
Immune cells [e. g., dendritic cells (DC) and natural killer (NK) cells] are critical players during the pre-placentation stage for successful mammalian pregnancy. Proper placental and fetal development relies on balanced ...