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Krüppel-like factor 6 interferes with cellular transformation induced by the H- ras oncogene
(Federation of American Societies for Experimental Biology, 2014-12)
KLF6 is a member of the Krüppel-like factor family of transcription factors with diverse roles in the regulation of cell physiology including proliferation, signal transduction, and apoptosis. Mutations or downregulation ...
Absence of caveolin-1 alters heat shock protein expression in spontaneous mammary tumors driven by Her-2/neu expression
(Springer, 2012-02)
In a previous study, we measured caveolin-1 protein levels, both in the normal breast and in breast cancer. The study revealed no association between caveolin-1 expression in the epithelial compartment and clinical disease ...
Linc00885 a novel oncogenic long non-coding rna associated with early stage breast cancer progression
(MDPI AG, 2020-10-08)
Long intergenic non-protein coding RNA 885 (LINC00885) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was to characterize the phenotypic effects and signaling ...
Krüppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene
(Federation of American Societies for Experimental Biology, 2014-12)
KLF6 is a member of the Krüppel-like factor family of transcription factors, with diverse roles in the regulation of cell physiology, including proliferation, signal transduction, and apoptosis. Mutations or down-regulation ...
Role of estrogen receptors, PKC and Src in ERK2 and p38 MAPK signaling triggered by 17β-estradiol in skeletal muscle cells
(Pergamon-Elsevier Science Ltd, 2010-10)
We have previously reported in C2C12 murine skeletal muscle cells that 10-8M 17β-estradiol promotes MAPKs stimulation which in turn mediates the activation of CREB and Elk-1 transcription factors. In this work, we demonstrated ...
Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
(Mary Ann Liebert, 2011-09)
p53 is a crucial transcription factor with tumor suppressive properties that elicits its function through specific target genes. It constitutes a pivotal system that integrates information received by many signaling pathways ...
Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
(MDPI, 2019-04)
Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed by lung cancer. Given the importance of BC in public health, it is essential to identify biomarkers to predict prognosis, predetermine ...
Bovine leukemia virus small noncoding RNAs are functional elements that regulate replication and contribute to oncogenesis in vivo
(2016-04)
Retroviruses are not expected to encode miRNAs because of the potential problem of self-cleavage of their genomic RNAs. This assumption has recently been challenged by experiments showing that bovine leukemia virus (BLV) ...
PI3K/Akt cooperates with oncogenic Notch by inducing nitric oxide-dependent inflammation
(Elsevier B.V., 2018-03)
The PI3K/Akt signaling pathway, Notch, and other oncogenes cooperate in the induction of aggressive cancers. Elucidating how the PI3K/Akt pathway facilitates tumorigenesis by other oncogenes may offer opportunities to ...
AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
(American Association for Cancer Research, 2014-12)
Cancer cells may overcome growth factor dependence by deregulating oncogenic and/or tumor-suppressor pathways that affect their metabolism, or by activating metabolic pathways de novo with targeted mutations in critical ...