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Follicular wave dynamics and Growth factors gene expression in Braford heifers
(Wiley, 2020-06)
The objectives of the present study were (experiment 1) to characterized development and dynamics of the dominant follicles (DF) and the corpus luteum (CL) to determine patterns of two (W2) and three (W3) follicular waves ...
A dioxin-like compound induces hyperplasia and branching morphogenesis in mouse mammary gland, through alterations in TGF-β1 and aryl hydrocarbon receptor signaling
(Academic Press Inc Elsevier Science, 2017-11)
Hexachlorobenzene (HCB) is a widespread environmental pollutant and a dioxin-like compound that binds weakly to the aryl hydrocarbon receptor (AhR). Because AhR and transforming growth factor β1 (TGF-β1) converge to regulate ...
FGF2 Induces Breast Cancer Growth through Ligand-Independent Activation and Recruitment of ERα and PRB∆4 Isoform to MYC Regulatory Sequences
(John Wiley & Sons Inc, 2019-03)
Progression to hormone-independent growth leading to endocrine therapy resistance occurs in a high proportion of patients with estrogen receptor alpha (ERα) and progesterone receptors (PR) positive breast cancer. We and ...
Convergent signaling pathways regulate parathyroid hormone and fibroblast growth factor-23 action on NPT2A-mediated phosphate transport
(American Society for Biochemistry and Molecular Biology, 2016-09)
Parathyroid hormone (PTH) and FGF23 are the primary hormones regulating acute phosphate homeostasis. Human renal proximal tubule cells (RPTECs) were used to characterize the mechanism and signaling pathways of PTH and FGF23 ...
Role of Peroxisome Proliferator Activated Receptor-Gamma in Bacillus Calmette-Guérin Bladder Cancer Therapy
(Elsevier Science Inc, 2012-12)
Purpose: We evaluated the effects of combined PPARg agonist with bacillus Calmette-Guérin in bladder cancer growth in vitro and in vivo, focusing on the tissue remodeling mechanisms induced by bacillus Calmette-Guérin. ...
Targeting FGFR with BGJ398 in breast cancer: Effect on tumor growth and metastasis
(Bentham Science Publishers, 2017-12)
AbstractBACKGROUND:Endocrine resistance and metastatic dissemination comprise major clinical challenges for breast cancer treatment. The fibroblast growth factor receptor family (FGFR) consists of four tyrosine kinase ...
Isolation and initial characterization of human glioblastoma cells resistant to photodynamic therapy
(Elsevier Science, 2021-03)
Glioblastoma is the most severe form of brain cancer. Despite multimodal therapy combining surgery, radiotherapy and chemotherapy, prognosis of patients is dismal. It has been observed that the surgical resection guided ...
Increased high molecular weight FGF2 in endocrine-resistant breast cancer
(Springer US, 2018-10)
Endocrine resistance may develop as a consequence of enhanced growth factor signaling. Fibroblast growth factor 2 (FGF2) consists of a low and several high molecular weight forms (HMW-FGF2). We previously demonstrated that ...
GDNF/GFRα1 Complex Abrogates Self-Renewing Activity of Cortical Neural Precursors Inducing Their Differentiation
(Cell Press, 2018-03)
The balance between factors leading to proliferation and differentiation of cortical neural precursors (CNPs) determines the correct cortical development. In this work, we show that GDNF and its receptor GFRα1 are expressed ...
Biomarkers of progression after HIV acute/early infection: Nothing compares to CD4+ T-cell count?
(MDPI AG, 2018-01)
Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection ...