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The shape of mitochondrial dysfunction in Down Syndrome
(John Wiley & Sons Inc, 2019-07)
Oxidative stress (OS) and mitochondrial dysfunction (MD) have been extensively studied and defined as therapeutic targets in Down syndrome (DS). Though originally associated to individual genes located in supernumerary ...
Levodopa Causes Striatal Cholinergic Interneuron Burst-Pause Activity in Parkinsonian Mice
(Wiley-liss, div John Wiley & Sons Inc., 2021-07)
Background: Enhanced striatal cholinergic interneuron activity contributes to the striatal hypercholinergic state in Parkinson's disease (PD) and to levodopa-induced dyskinesia. In severe PD, dyskinesia and motor fluctuations ...
Stress related hormonal circuitry in chagas disease
(IOS Press, 2014-07)
During stressful processes, for example infectious diseases, neuroendocrine and immune networks act multi-directionally facilitating the host response. However in exacerbated settings, this homeostatic mechanism may be ...
Molecular characterization of giardia duodenalis and evidence for cross‐species transmission in Northern Argentina
(Wiley Blackwell Publishing, Inc, 2021-07)
Anthropogenic activities, such as human population expansion and land-use change, create ecological overlap between humans, domesticated animals, and wildlife and can exacerbate the zoonotic transmission of parasites. To ...
Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity
(Cell Press, 2017-02)
Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling ...
Exhaled nitric oxide predicts loss of asthma control in children after inhaled corticosteroids withdrawal
(Veterinary and Human Toxicology, 2019-05-27)
Background: Exhaled nitric oxide (eNO) has been proposed for monitoring airway inflammation, diagnosis, and prediction of steroid responsiveness in asthma. However, its utility after elective suspension of asthma medication ...
Molecular evidence of Chlamydia pneumoniae infection in reptiles in Argentina
(Asociación Argentina de Microbiología, 2014-02)
In the central area of Argentina, the epidemiological and molecular characteristics of Chlamydia pneumoniae infections in reptiles are still unknown. A nested polymerase chain reaction of the rpoB gene was used to detect ...
Wnt/β-catenin pathway in the prefrontal cortex is required for cocaine-induced neuroadaptations
(Wiley Blackwell Publishing, Inc, 2017-07)
Behavioral sensitization is a progressive and enduring enhancement of the motor stimulant effects elicited by repeated administration of drugs of abuse. It can be divided into two distinct temporal and anatomical domains, ...
AMPK-dependent nitric oxide release provides contractile support during hyperosmotic stress
(Dr Dietrich Steinkopff Verlag, 2018-01)
In different pathological situations, cardiac cells undergo hyperosmotic stress (HS) and cell shrinkage. This change in cellular volume has been associated with contractile dysfunction and cell death. Given that nitric ...
Eutrophication disrupts summer trophic links in an estuarine microbial food web
(Elsevier Inc, 2019-09-21)
Eutrophication is the most widespread effect of urban development in coastal areas. To elucidate how nutrient loading affects the carbon pathways at the base of food chains, we quantified the carbon transfer among microbial ...