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Neurotoxicity of the pesticide rotenone on neuronal polarization: A mechanistic approach
(Shenyang Editorial Dept Neural Regeneration Res, 2019-05)
Neurons are the most extensive and polarized cells that display a unique single long axon and multiple dendrites, which are compartments exhibiting structural and functional differences. Polarity occurs early in neuronal ...
Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells
(Impact Journals, 2018-05-04)
Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy. This ...
Physiological Functions and Regulation of the Na+/H+ Exchanger [NHE1] in Renal Tubule Epithelial Cells
(Karger, 2015-08)
The sodium-hydrogen exchanger isoform-1 [NHE1] is a ubiquitously expressed plasma membrane protein that plays a central role in intracellular pH and cell volume homeostasis by catalyzing an electroneutral exchange of ...
Damaging effects of BMAA on retina neurons and Müller glial cells
(Elsevier Science Ltd, 2020-11-01)
B–N-methylamino-L-alanine (BMAA), a cyanotoxin produced by most cyanobacteria, has been proposed to cause long term damages leading to neurodegenerative diseases, including Amyotrophic Lateral Sclerosis/Parkinsonism Dementia ...
Egg proteomic characterization of Seriola rivoliana in captivity
(Pontificia Universidad Católica de Valparaíso, 2020)
Chloroplasts alter their morphology and accumulate at the pathogen interface during infection by Phytophthora infestans
(Wiley Blackwell Publishing, Inc, 2021-09)
Upon immune activation, chloroplasts switch off photosynthesis, produce antimicrobial compounds and associate with the nucleus through tubular extensions called stromules. Although it is well established that chloroplasts ...
Angiotensin ii type 2 receptor agonist, compound 21, prevents tubular epithelial cell damage caused by renal ischemia
(Pergamon-Elsevier Science Ltd, 2021-12)
During ischemic acute kidney injury (AKI), loss of cytoskeletal integrity and disruption of intercellular junctions are rapid events in response to ATP depletion. Angiotensin II type 2 receptor (AT2R) is overexpressed in ...
Synthesis of a novel analog of calcitriol and its biological evaluation as antitumor agent
(Pergamon-Elsevier Science Ltd, 2019-01-17)
Calcitriol analogs have shown promising potential as compounds to be used in cancer chemotherapy. This report presents the synthesis of a novel vitamin D3 derivative with an amide and a carboxyl group in its side chain, ...
FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
(Elsevier, 2021-11)
Despite the undisputable role of the small GTPase Rac1 in the regulation of actin cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) involved in Rac1-mediated motility and invasion in human ...
Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve Injury
(Society for Neuroscience, 2020-03)
In contrast to neurons in the CNS, damaged neurons from the peripheral nervous system (PNS) regenerate, but this process can be slow and imperfect. Successful regeneration is orchestrated by cytoskeletal reorganization at ...