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Comparative analysis of antimicrobial resistance in enterotoxigenic Escherichia coli isolates from two paediatric cohort studies in Lima, Peru
(Oxford University Press, 2015)
BACKGROUND: Antibiotic resistance is increasing worldwide, being of special concern in low- and middle-income countries. The aim of this study was to determine the antimicrobial susceptibility and mechanisms of resistance ...
Defining catastrophic costs and comparing their importance for adverse tuberculosis outcome with multi-drug resistance: a prospective cohort study, Peru
(Public Library of Science, 2014)
BACKGROUND: Even when tuberculosis (TB) treatment is free, hidden costs incurred by patients and their households (TB-affected households) may worsen poverty and health. Extreme TB-associated costs have been termed ...
Mortality from drug-resistant tuberculosis in high-burden countries comparing routine drug susceptibility testing with whole-genome sequencing: a multicentre cohort study
(Elsevier, 2021)
Background: Drug resistance threatens global tuberculosis control. We aimed to examine mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug ...
Transgender Women Living with HIV Frequently Take Antiretroviral Therapy and/or Feminizing Hormone Therapy Differently Than Prescribed Due to Drug–Drug Interaction Concerns
(Mary Ann Liebert Inc., 2017-10)
Purpose: Both hormone therapy (HT) and antiretroviral therapy (ART) can be lifesaving for transgender women (TW) living with HIV, but each has side effects and potential drug-drug interactions (DDI). We assessed how concerns ...
Hydatid Disease: Current Status Of Chemotherapy And Drug Delivery Systems
(Betham Science, 2013-07)
Human echinococcosis or hydatid disease still causes serious health problems with a worldwide geographical distribution. This parasitic infection is a chronic, complex, and still neglected disease. Currently four treatment ...
Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study
(Elsevier, 2014)
BACKGROUND: Clinical effectiveness of previous regimens to treat Plasmodium vivax infection have been hampered by compliance. We aimed to assess the dose-response, safety, and tolerability of single-dose tafenoquine plus ...
5-Fluorouracil-loaded ultradeformable liposomes for skin therapy
(American Institute of Physics Inc., 2018-07)
5-Fluorouracil (5FU) is an antineoplastic drug with a poor percutaneous permeation. For this reason, its efficacy for topical treatments is reduced to superficial or advanced skin lesions (that have already damaged the ...
Mucoadhesive and responsive nanogels as carriers for sustainable delivery of timolol for glaucoma therapy
(Elsevier Science, 2021-01)
Topical administration to the eye for the treatment of glaucoma is a convenient route because it increases the patient comfort. Timolol can efficiently diminish the intraocular pressure (IOP) of the eye; however the topical ...
Thinking small, doing big: Current success and future trends in drug delivery systems for improving cancer therapy with special focus on liver cancer
(Elsevier Science, 2019-02-01)
Nanotechnology has recently emerged as a promising tool in biomedicine research. An important branch of nanotechnology is drug delivery and drug targeting using a wide range of biomaterials with promising potential ...
Additional evidence to support the phasing-out of treatment category II regimen for pulmonary tuberculosis in Peru
(Oxford University Press, 2012)
The effectiveness of the World Health Organization's (WHO) treatment category II regimen for tuberculosis in 124 patients was compared to that of 1147 patients receiving treatment category I in Lima, Peru following WHO's ...