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Tankyrase inhibitors hinder Trypanosoma cruzi infection by altering host-cell signalling pathways
(Cambridge University Press, 2021-09)
Chagas disease is a potentially life-threatening protozoan infection affecting around 8 million people, for which only chemotherapies with limited efficacy and severe adverse secondary effects are available. The etiological ...
Prefrontal cortex-driven dopamine signals in the striatum show unique spatial and pharmacological properties
(Society for Neuroscience, 2020-09-28)
Dopamine (DA) signals in the striatum are critical for a variety of vital processes, including motivation, motor learning, and reinforcement learning. Striatal DA signals can be evoked by direct activation of inputs from ...
Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
(Mary Ann Liebert, 2011-09)
p53 is a crucial transcription factor with tumor suppressive properties that elicits its function through specific target genes. It constitutes a pivotal system that integrates information received by many signaling pathways ...
Indistinguishability and negative probabilities
(Multidisciplinary Digital Publishing Institute, 2020-07-20)
In this paper, we examined the connection between quantum systems’ indistinguishability and signed (or negative) probabilities. We do so by first introducing a measure-theoretic definition of signed probabilities inspired ...