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Mostrando ítems 61-70 de 70
Large-Scale Multiplexing Permits Full-Length Transcriptome Annotation of 32 Bovine Tissues From a Single Nanopore Flow Cell
(Frontiers Media, 2021-05)
A comprehensive annotation of transcript isoforms in domesticated species is lacking. Especially considering that transcriptome complexity and splicing patterns are not wellconserved between species, this presents a ...
ApoER2 and Reelin are expressed in regenerating peripheral nerve and regulate Schwann cell migration by activating the Rac1 GEF protein, Tiam1
(Academic Press Inc Elsevier Science, 2015-11)
ApoER2 and its ligand Reelin participate in neuronal migration during development. Upon receptor binding, Reelin induces the proteolytic processing of ApoER2 as well as the activation of signaling pathway, including small ...
Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer
(Springer Nature, 2022)
Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and progesterone receptors and the lack of membrane overexpression or gene amplification of receptor tyrosine kinase ErbB-2/HER2. Due ...
Angiotensin II-upregulated MAP kinase phosphatase-3 modulates FOXO1 and p21 in adrenocortical H295R cells
(Cell Press, 2020-03)
MAPK phosphatases (MKP) downregulate the activity of mitogen-activated protein kinases (MAPK), such asERK1/2, and modulate the processes regulated by these kinases. ERK1/2 participate in a wide range of processesincluding ...
Calcium channels and synaptic transmission in familial hemiplegic migraine type 1 animal models
(Springer Verlag Berlín, 2014)
Novel antibodies directed against the human erythropoietin receptor: Creating a basis for clinical implementation
(Wiley, 2014)
Recombinant human erythropoietin (rHuEPO) is an effective treatment for anaemia but concerns that it causes disease progression in cancer patients by activation of EPO receptors (EPOR) in tumour tissue have been controversial ...
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases
(American Society for Clinical Investigation, 2020-04)
BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available ...