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Molecular recognition and binding mechanism of N-alkyl- benzyltetrahydroisoquinolines to the D1 dopamine receptor. A computational approach
(Elsevier Science, 2003-12)
In order to better understand, at sub-molecular level, the minimal structural requirements for the recognition process in the inhibitory activity, a series of N-alkyl-benzyltethrahydroisoquinolines (BTHIQs) were examined ...
Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
(Cell Press, 2018-05)
Dopamine input to the dorsal and ventral striatum originates from separate populations of midbrain neurons. Despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded ...
Dopamine D 4 receptor, but not the ADHD-associated D 4.7 variant, forms functional heteromers with the dopamine D 2S receptor in the brain
(Nature Publishing Group, 2012-06)
Polymorphic variants of the dopamine D 4 receptor have been consistently associated with attention-deficit hyperactivity disorder (ADHD). However, the functional significance of the risk polymorphism (variable number of ...
Effects of chronic fructose overload on renal dopaminergic system: alteration of urinary L-dopa/dopamine index correlates to hypertension and precedes kidney structural damage
(Elsevier Science Inc, 2018-01)
Insulin resistance induced by a high-fructose diet has been associated to hypertension and renal damage. The aim of this work was to assess alterations in the urinary L-dopa/dopamine ratio over three time periods in rats ...
Fused and unzipped carbon nanotubes, electrochemically treated, for selective determination of dopamine and serotonin
(Pergamon-Elsevier Science Ltd, 2018-09)
Glassy carbon electrodes (GC) were modified with multiwalled carbon nanotubes (MWCNT/GC) and electrochemically treated first by applying an oxidation potential and then a reduction potential. The resulting electrodes were ...
Inducible ablation of dopamine D2 receptors in adult mice impairs locomotion, motor skill learning and leads to severe parkinsonism
(Nature Publishing Group, 2016-07)
Motor execution and planning are tightly regulated by dopamine D1 and D2 receptors present in basal ganglia circuits. Although stimulation of D1 receptors is known to enhance motor function, the global effect of D2 receptor ...
Ghrelin Recruits Specific Subsets of Dopamine and GABA Neurons of Different Ventral Tegmental Area Sub-nuclei
(Pergamon-Elsevier Science Ltd, 2018-11)
Ghrelin is a stomach-derived hormone that regulates rewarding behaviors and reinforcement by acting on the ventral tegmental area (VTA). The VTA is a complex midbrain structure mainly comprised of dopamine (DA) and ...
Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment
(Pergamon-Elsevier Science Ltd, 2011-12)
Motor activity induced in the Circling Training test (CT) during a postnatal (PN) critical period of plasticity (PN30-37) produces a long-lasting decrease in the number of binding sites and mRNA expression levels of the ...
The dopamine receptor agonist apomorphine stabilizes neurotoxic α-synuclein oligomers
(John Wiley & Sons Inc., 2022-02)
The misfolding and aggregation of the protein α-synuclein (aSyn) into potentially neurotoxic oligomers is believed to play a pivotal role in the neuropathogenesis of Parkinson’s disease (PD). Herein, we explore how apomorphine ...