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Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors
(Wiley Blackwell Publishing, Inc, 2009-09-10)
The insulin receptor (ir) and ir signaling proteins are widely distributed throughout the cns. ir signaling provides a trophic signal for transformed retinal neurons in culture and we recently reported that deletion of ir ...
More than tracks: how the cytoskeleton builds epithelia asymmetry
(Universidad Nacional de La Plata. Facultad de Medicina. Centro de Investigaciones Cardiovasculares. Sociedad Argentina de Fisiología, 2018-04)
Epithelia are three-dimensional arrangements of cells organized into structures which delimit morphologically and physiologically different compartments. At the cellular level, epithelial cells are characterized by the ...
Extracellular matrix stiffness negatively affects axon elongation, growth cone area and F-actin levels in a collagen type I 3D culture
(John Wiley & Sons Ltd, 2021-11)
Three dimensional (3D) in vitro neuronal cultures can better reproduce physiologically relevant phenotypes compared to 2D-cultures, because in vivo neurons reside in a 3D microenvironment. Interest in neuronal 3D cultures ...
Telomere-led meiotic chromosome movements: recent update in structure and function
(Taylor & Francis, 2020-01)
In S. cerevisiae prophase meiotic chromosomes move by forces generated in the cytoplasm and transduced to the telomere via a protein complex located in the nuclear membrane. We know that chromosome movements require actin ...
Ulipristal acetate interferes with actin remodeling induced by 17β-estradiol and progesterone in human endometrial stromal cells
(Frontiers Research Foundation, 2018-06)
Ulipristal acetate (UPA) is a selective progesterone receptor modulator (SPRM) used for emergency contraception and for the medical management of symptomatic uterine fibroids (UF). Treatment with UPA turns in amenorrhea ...
Cyclic AMP efflux through MRP4 regulates actin dynamics signalling pathway and sperm motility in bovines
(Nature, 2020-09)
Previously we demonstrated that multidrug resistance-associated protein 4 transporter (MRP4) mediates cAMP efflux in bovine spermatozoa and that extracellular cAMP (ecAMP) triggers events associated to capacitation. Here, ...
Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications
(American Physiological Society, 2020-02)
The pedunculopontine nucleus (PPN) is part of the reticular activating system (RAS) in charge of arousal and rapid eye movement sleep. The presence of high-frequency membrane oscillations in the gamma-band range in the PPN ...
The early molecular events leading to COFILIN phosphorylation during mouse sperm capacitation are essential for acrosomal exocytosis
(American Society for Biochemistry and Molecular Biology, 2022-06)
The actin cytoskeleton reorganization during sperm capacitation is essential for the occurrence of acrosomal exocytosis (AR) in several mammalian species. Here, we demonstrate that in mouse sperm, within the first minutes ...
Galectin-3 Exerts a Pro-differentiating and Pro-myelinating Effect Within a Temporal Window Spanning Precursors and Pre-oligodendrocytes: Insights into the Mechanisms of Action
(Humana Press, 2019-10)
Oligodendrocytes (OLG) are the cells resident in the CNS responsible for myelination. OLG undergo a succession of morphological and molecular changes along several maturational stages. Galectin-3 (Gal-3) is a 25- to 35-KDa ...