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DNA thermodynamic pressure: A potential contributor to genome evolution
(Oxford University Press, 2002)
Codon usage bias is a feature of living organisms. The origin of this bias might be explained not only by external factors but also by the nature of the structure of deoxyribonucleic acid (DNA) itself. We have developed a ...
Establecimiento in vitro de arándano (Vaccinium corymbosum L)
(2013)
Blueberry is a shrub of the Ericaceae family, that belongs to the genus Vaccinium, which comprises several species, among them V. corymbosum. Due to the high medicinal and nutritional value of the fruit, these plants are ...
A comprehensive analysis of the computed tautomer fractions of the imidazole ring of histidines in Loligo vulgaris
(Adenine Press, 2017-09)
A recently introduced electrostatic-based method to determine the pKa values of ionizable residues and fractions of ionized and tautomeric forms of histidine (His) and acid residues in proteins, at a given fixed pH, is ...
Coupled molecular dynamics and continuum electrostatic method to compute the ionization pKa’s of proteins as a function of pH. Test on a large set of proteins
(Adenine Press, 2018-02-24)
A computational method, to predict the pKa values of the ionizable residues Asp, Glu, His, Tyr, and Lys of proteins, is presented here. Calculation of the electrostatic free-energy of the proteins is based on an efficient ...
A new analogue of islet neogenesis associated protein with higher structural and plasma stability
(Adenine Press, 2021-01)
Islet Neogenesis Associated Protein pentadecapeptide (INGAP-PP) increases β-cell mass and function in experimental animals. A short clinical trial also yielded promising results. However, HTD4010, a new peptide derived ...
Orthosteric and benzodiazepine cavities of the α1β2γ2 GABAA receptor: insights from experimentally validated in silico methods
(Adenine Press, 2019-05-04)
γ-aminobutyric acid-type A (GABA A ) receptors mediate fast synaptic inhibition in the central nervous system of mammals. They are modulated via several sites by numerous compounds, which include GABA, benzodiazepines, ...
New substituted aminopyrimidine derivatives as BACE1 inhibitors: in silico design, synthesis and biological assays
(Adenine Press, 2019-01)
We report in this work new substituted aminopyrimidine derivatives acting as inhibitors of the catalytic site of BACE1. These compounds were obtained from a molecular modeling study. The theoretical and experimental study ...
Efficient direct shoot organogenesis and genetic stability in micropropagated sacha inchi (Plukenetia volubilis L.)
(BioMed Central Ltd., 2020-09-03)
Objective: It is necessary to improve biotech platforms based on in vitro cell tissue culture to support sacha inchi (Plukenetia volubilis L.) research programs and draw on the nutritional value of the high polyunsaturated ...
Efficient direct shoot organogenesis and genetic stability in micropropagated sacha inchi (Plukenetia volubilis L.)
(BioMed Central Ltd., 2020-09-03)
Objective: It is necessary to improve biotech platforms based on in vitro cell tissue culture to support sacha inchi (Plukenetia volubilis L.) research programs and draw on the nutritional value of the high polyunsaturated ...
Fabrication of a novel impedimetric biosensor for label free detection of DNA damage induced by doxorubicin
(Elsevier Science, 2019-02)
In this work, a novel impedimetric biosensor has been fabricated for detection of DNA damage induced by doxorubicin (DX). Cytochrome P450 reductase (CPR) is required for electron transfer from nicotinamide adenine dinucleotide ...