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Selective Interaction of Colistin with Lipid Model Membranes
(Cell Press, 2018-02)
Although colistin's clinical use is limited due to its nephrotoxicity, colistin is considered to be an antibiotic of last resort because it is used to treat patients infected with multidrug-resistant bacteria. In an effort ...
Transmembrane domain dimerization induces cholesterol rafts in curved lipid bilayers
(Royal Society of Chemistry, 2019-01)
Are the dimerization of transmembrane (TM) domains and the reorganization of the lipid bilayer two independent events? Does one event induce or interfere with the other? In this work, we have performed well-tempered ...
Filopodia formation driven by membrane glycoprotein M6a depends on the interaction of its transmembrane domains
(Wiley Blackwell Publishing, Inc, 2015-08)
Membrane glycoprotein M6a, which belongs to the tetraspan proteolipid protein family, promotes structural plasticity in neurons and cell lines by unknown mechanisms. This glycoprotein is encoded by Gpm6a, a stress-regulated ...
Brucella abortus MFP: A Trimeric Coiled-Coil Protein with Membrane Fusogenic Activity
(American Chemical Society, 2008-12)
The bacterial genus Brucella consists of a group of facultative intracellular pathogens which produces abortion and infertility in animals and a chronic debilitating febrile illness in humans. BMFP is a basic protein of ...
ER–plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis
(Nature Publishing Group, 2017-07)
The double‐membrane‐bound autophagosome is formed by the closure of a structure called the phagophore, origin of which is still unclear. The endoplasmic reticulum (ER) is clearly implicated in autophagosome biogenesis due ...
Phase-segregated membrane model assessed by a combined SPR-AFM approach
(Elsevier Science, 2018-12)
Model biomembranes can provide valuable insights into the properties of complex biological membranes. Among several techniques, Surface Plasmon Resonance (SPR) provides a label-free analysis of the interactions of bioactive ...
Functional and structural comparison of the ABC exporter MsbA studied in detergent and reconstituted in nanodiscs
(Academic Press Inc Elsevier Science, 2019-05)
Purified membrane proteins are most frequently studied solubilized in detergent, but the properties of detergent micelles are very different from those of lipid bilayers. Therefore, there is an increasing interest in ...
Relevance of CARC and CRAC Cholesterol-Recognition Motifs in the Nicotinic Acetylcholine Receptor and Other Membrane-Bound Receptors
(Elsevier Academic Press Inc, 2017-07)
Cholesterol is a ubiquitous neutral lipid, which finely tunes the activity of a wide range of membrane proteins, including neurotransmitter and hormone receptors and ion channels. Given the scarcity of available X-ray ...
Review: placental syncytiotrophoblast membranes - domains, subdomains and microdomainsPLACENTAPLACENTA
(WB SAUNDERS CO LTD, 2011)
Differential dynamic and structural behavior of lipid-cholesterol domains in model membranesPLOS ONEPLOS ONE
(PUBLIC LIBRARY SCIENCE, 2016)