Buscar
Mostrando ítems 31-40 de 101
Polycystin-2 (TRPP2) regulation by Ca2+ is effected and diversified by actin-binding proteins
(Cell Press, 2015-05)
Calcium regulation of Ca2+-permeable ion channels is an important mechanism in the control of cell function. Polycystin-2 (PC2, TRPP2), a member of the transient receptor potential superfamily, is a nonselective cation ...
Transition to superdiffusive behavior in intracellular actin-based transport mediated by molecular motors
(American Physical Society, 2009-12)
Intracellular transport of large cargoes, such as organelles, vesicles, or large proteins, is a complex dynamical process that involves the interplay of adenosine triphosphate-consuming molecular motors, cytoskeleton ...
A feed-forward mechanism involving the NOX complex and RyR-mediated ca2 + release during axonal specification
(Society for Neuroscience, 2016-10)
Physiological levels of ROS support neurite outgrowth and axonal specification, but the mechanisms by which ROS are able to shape neurons remain unknown. Ca2 +, a broad intracellular second messenger, promotes both Rac1 ...
Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53
(Frontiers Media, 2020-11)
Missense mutations in the TP53 gene are among the most frequent alterations in human cancer. Consequently, many tumors show high expression of p53 point mutants, which may acquire novel activities that contribute to develop ...
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing
(Academic Press Inc Elsevier Science, 2020-07-11)
Long-term memory has been associated with morphological changes in the brain, which in turn tightly correlate with changes in synaptic efficacy. Such plasticity is proposed to rely on dendritic spines as a neuronal canvas ...
Apparent stiffness of vimentin intermediate filaments in living cells and its relation with other cytoskeletal polymers
(Elsevier Science, 2020-08)
The cytoskeleton is a complex network of interconnected biopolymers intimately involved in the generation and transmission of forces. Several mechanical properties of microtubules and actin filaments have been extensively ...
Glypican-3 regulates migration, adhesion and actin cytoskeleton organization in mammary tumor cells through Wnt signaling modulation
(Springer, 2008-04)
Glypican-3 (GPC3) is a proteoglycan involved in migration, proliferation and cell survival modulation in several tissues. There are many reports demonstrating a downregulation of GPC3 expression in some human tumors, ...
Disassembly of F-Actin Cytoskeleton after Interaction of Bacillus cereus with Fully Differentiated Human Intestinal Caco-2 Cells
(American Society for Microbiology, 2004-06)
In the present study the role of direct procaryote-eucaryote interactions in the virulence of Bacillus cereus has been investigated. As a model of human enterocytes, differentiated Caco-2 cells were used. Infection of fully ...
Mitogen-activated protein kinases are involved in hepatocanalicular dysfunction and cholestasis induced by oxidative stress
(Springer, 2017-06)
In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca2+-dependent protein kinase C isoforms (cPKC), ...