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Electrophysiological effects of tamoxifen: mechanism of protection against reperfusion arrhythmias in isolated rat hearts
(Lippincott Williams, 2013-08)
Reperfusion arrhythmias are currently attributed to ionic imbalance and oxidative stress. Tamoxifen is a potent antioxidant that also modulates some ionic transport pathways. In this work, we tried to correlate the ...
Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K + currents in adult murine atria
(American Physiological Society, 2018-05)
G protein-gated inwardly rectifying K+ (GIRK) channels are the major inwardly rectifying K+ currents in cardiac atrial myocytes and an important determinant of atrial electrophysiology. Inhibitory G protein α-subunits can ...
A novel pharmacological activity of caffeine in the cholinergic system
(Pergamon-Elsevier Science Ltd, 2018-06)
Cholinergic deficit is regarded as an important factor responsible for Alzheimer's disease (AD) symptoms. Acetylcholinesterase (AChE) and nicotinic receptor (AChR) are two molecular targets for the treatment of this disease. ...
Spatial Repellency Caused by Volatile Pyrethroids is Olfactory-Mediated in the German Cockroach Blattella germanica (Dictyoptera: Blattellidae)
(Sociedade Entomológica do Brasil, 2019-10)
Pyrethroids are synthetic insecticides that have a repellent action. This effect has been associated with an increase in the locomotor activity, which causes the avoidance of the insecticide-treated area (excito-repellency). ...
The Drosophila Neuropeptides PDF and sNPF Have Opposing Electrophysiological and Molecular Effects on Central Neurons
(American Physiological Society, 2014-03)
Neuropeptides have widespread effects on behavior, but how these molecules alter the activity of their target cells is poorly understood. We employed a new model system in Drosophila melanogaster to assess the electrophysiological ...
Gonadal hormone-independent sex differences in GABAA receptor activation in rat embryonic hypothalamic neurons
(Wiley Blackwell Publishing, Inc, 2020-03)
Background and Purpose: GABAA receptor functions are dependent on subunit composition, and, through their activation, GABA can exert trophic actions in immature neurons. Although several sex differences in GABA-mediated ...
Identification and electrophysiological properties of a sphingosine-dependent plasma membrane Ca2+ channel in Trypanosoma cruzi
(Wiley Blackwell Publishing, Inc, 2019-10)
Trypanosoma cruzi is the causative agent of Chagas disease. The only two drugs accepted for the treatment of this infection are benznidazole and nifurtimox, which are of limited use in the predominant chronic phase. On the ...
Store depletion induces Gαq-mediated PLCβ1 activity to stimulate TRPC1 channels in vascular smooth muscle cells
(Federation of American Societies for Experimental Biology, 2016-02)
Depletion of sarcoplasmic reticulum (SR) Ca2+ stores activates store-operated channels (SOCs) composed of canonical transient receptor potential (TRPC) 1 proteins in vascular smooth muscle cells (VSMCs), which contribute ...
Interneuron NMDA receptor ablation induces hippocampus-prefrontal cortex functional hypoconnectivity after adolescence in a mouse model of schizophrenia
(Society for Neuroscience, 2020-04)
Although the etiology of schizophrenia is still unknown, it is accepted to be a neurodevelopmental disorder that results from the interaction of genetic vulnerabilities and environmental insults. Although schizophrenia’s ...
Loss of homeostasis in the direct pathway in a mouse model of asymptomatic Parkinson’s disease
(Society for Neuroscience, 2016-05)
The characteristic slowness of movement in Parkinson's disease relates to an imbalance in the activity of striatal medium spiny neurons (MSNs) of the direct (dMSNs) and indirect (iMSNs) pathways. However, it is still unclear ...