Buscar
Mostrando ítems 11-20 de 1040
Shear behaviour of brick-mortar interface in CFRP retrofitted or repaired masonry
(Pergamon-Elsevier Science Ltd, 2010-04)
There are many unreinforced masonry buildings all over the world. Many of them are located in seismic zones and are, therefore, susceptible to lateral forces caused by earthquakes. The transmission of these forces to the ...
Major roles of for pyrimidine dimers, nucleotide excision repair and ATR in the alternative splicing response to UV irradiation
(Elsevier B.V., 2017-03-21)
We have previously found that UV irradiation promotes RNA polymerase II (RNAPII) hyperphosphorylation and subsequent changes in alternative splicing (AS). We show now that UV-induced DNA damage is not only necessary but ...
Surgical Technique for Whistler Deformity Repair in Bilateral Cleft Lip Patients: An Anthropometric Study
(Wolters Kluwer Health, 2016)
Objective: The purpose of this study was to evaluate the surgical outcome of secondary bilateral cleft lips after using a surgical technique for whistler deformity repair. Design: A prospective cohort study of one surgeon's ...
Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA
(Elsevier Science, 2018-03)
Biallelic mutations of FANCD2 and other components of the Fanconi Anemia (FA) pathway cause a disease characterized by bone marrow failure, cancer predisposition and a striking sensitivity to agents that induce crosslinks ...
Damage and repair of the axolemmal membrane: From neural development to axonal trauma and restoration
(Elsevier Academic Press Inc., 2019-10)
Integrity of the plasma membrane is essential for the maintenance of physiological conditions, metabolic activity and the shape of eukaryotic cells. In neurons, the plasma membrane surrounding the axon—the axolemma—fulfills ...
Hypermutation in burkholderia cepacia complex is mediated by DNA mismatch repair inactivation and is highly prevalent in cystic fibrosis chronic respiratory infection
(Elsevier Gmbh, 2014-08)
The Burkholderia cepacia complex (Bcc) represents an important group of pathogens involved in long-term lung infection in cystic fibrosis (CF) patients. A positive selection of hypermutators, linked to antimicrobial ...
Emerging Therapeutic Targets Against Toxoplasma gondii: Update on DNA Repair Response Inhibitors and Genotoxic Drugs
(Frontiers Media S.A., 2020-06)
Toxoplasma gondii is the causative agent of toxoplasmosis in animals and humans. This infection is transmitted to humans through oocysts released in the feces of the felines into the environment or by ingestion of undercooked ...
DNA mismatch repair activity of MutLα is regulated by CK2-dependent phosphorylation of MLH1 (S477)
(Wiley-liss, Div John Wiley & Sons Inc, 2018-12)
MutLα, a heterodimer consisting of MLH1 and PMS2, is a key player of DNA mismatch repair (MMR), yet little is known about its regulation. In this study, we used mass spectrometry to identify phosphorylated residues within ...