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The mKATP Channels and protein-kinase C Are Involved in the Cardioprotective Effects of Genistein on Estrogen-Deficient Rat Hearts Exposed to Ischemia/Reperfusion
(Lippincott Williams, 2020-05)
Estrogenic deficiency is considered a risk of coronary disease in women. The phytoestrogen genistein could be a safe preventive strategy. The first aim of this work was to validate a model of cardiac stunning in which ...
Ischemia - Reperfusion: A look from yeast mitochondria
(Bentham Science Publishers, 2011-08)
The apoptotic phenomena observed in tissues which are subdued to ischemia and then to technical therapeutics of perfusion keep causing serious problems in the patient´s clinical recovery. Then, they constitute a challenge ...
Menhaden oil rich diet and experimental renal damage due to ischemia reperfusion
(Japan Oil Chemists Society, 2017-10)
Renal necrosis can be induced in weanling rats due to choline deficient diet. Menhaden oil has a protective effect against the development of renal necrosis in choline deficient weanling rats. The aim of this work was to ...
Effects of wortmannin on cardioprotection exerted by ischemic preconditioning in rat hearts subjected to ischemia-reperfusion
(Servicio Publicaciones Universidad Navarra, 2016-03)
Ischemic preconditioning (IPC) is one of the most powerful interventions to reduce ischemia-reperfusion injury. The aim of the present study was to investigate the involvement of the phosphatidylinositol-3-kinases (PI3Ks) ...
Gαi2 - and Gαi3-deficient mice display opposite severity of myocardial ischemia reperfusion injury
(Public Library of Science, 2014-05)
G-protein-coupled receptors (GPCRs) are the most abundant receptors in the heart and therefore are common targets for cardiovascular therapeutics. The activated GPCRs transduce their signals via heterotrimeric G-proteins. ...
Differential effects of AMP-activated protein kinase in isolated rat atria subjected to simulated ischemia–reperfusion depending on the energetic substrates available
(Springer, 2018-02)
AMP-activated protein kinase (AMPK) is a serine–threonine kinase that functions primarily as a metabolic sensor to coordinate anabolic and catabolic processes in the cell, via phosphorylation of multiple proteins involved ...
Rosuvastatin protects isolated hearts against ischemia-reperfusion injury: role of Akt-GSK-3β, metabolic environment, and mitochondrial permeability transition pore
(Servicio Publicaciones Universidad Navarra, 2020-01)
The cardioprotective activity of rosuvastatin (R) is yet to be known. The objective of this study was to research whether R perfusion before global ischemia can mitigate myocardial ischemia-reperfusion damage, considering ...
Involvement of energetic metabolism in the effects of ischemic postconditioning on the ischemic-reperfused heart of fed and fasted rats
(Springer Tokyo, 2011-07)
The effects of ischemic-postconditioning (IPOC) on functional recovery and cell viability of ischemic-reperfused hearts from fed and fasted rats were studied in relation to triacylglycerol and glycogen mobilization, ATP ...
Proteome variation of the rat liver after static cold storage assayed in an ex vivo model
(Academic Press Inc Elsevier Science, 2018-12)
Cold storage is a common procedure for liver preservation in a transplant setting. However, during cold ischemia, the liver suffers molecular alterations that can affect its performance. Also, deleterious mechanisms set ...
Protecting the heart from ischemia/reperfusion injury: an update on remote ischemic preconditioning and postconditioning
(Lippincott Williams, 2017-11-01)
Purpose of review: The most effective strategy for reducing acute myocardial ischemic injury is timely and effective reperfusion. However, myocardial reperfusion can induce further cardiomyocyte death (reperfusion injury). ...