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Mostrando ítems 11-20 de 36
Generic Vancomycin Enriches Resistant Subpopulations of Staphylococcus aureus after Exposure in a Neutropenic Mouse Thigh Infection Model
(American Society for MicrobiologyGRIPE: Grupo Investigador de Problemas en Enfermedades InfecciosasWashington, Estados Unidos, 2022)
Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study
(Elsevier, 2014)
BACKGROUND: Clinical effectiveness of previous regimens to treat Plasmodium vivax infection have been hampered by compliance. We aimed to assess the dose-response, safety, and tolerability of single-dose tafenoquine plus ...
Recent advances in micro-electro-mechanical devices for controlled drug release applications
(Frontiers Media S.A., 2020-06)
In recent years, controlled release of drugs has posed numerous challenges with the aim of optimizing parameters such as the release of the suitable quantity of drugs in the right site at the right time with the least ...
New old challenges in tuberculosis: Potentially effective nanotechnologies in drug delivery
(Elsevier Science, 2010-03)
Tuberculosis (TB) is the second most deadly infectious disease. Despite potentially curative pharmacotherapies being available for over 50 years, the length of the treatment and the pill burden can hamper patient lifestyle. ...
Direct thrombin inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in people with non-valvular atrial fibrillation
(Wiley, 2014)
BACKGROUND: Chronic anticoagulation with vitamin K antagonists (VKAs) prevents ischaemic stroke and systemic embolism in people with non-valvular atrial fibrillation (AF) but dose adjustment, coagulation monitoring and ...
Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field
(Taylor, 2014-02)
Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of ...
Efficacy of combined antiparasitic therapy with praziquantel and albendazole for neurocysticercosis: a double-blind, randomised controlled trial
(Elsevier, 2014)
BACKGROUND: Neurocysticercosis causes a substantial burden of seizure disorders worldwide. Treatment with either praziquantel or albendazole has suboptimum efficacy. We aimed to establish whether combination of these drugs ...
Current drug therapy and pharmaceutical challenges for Chagas disease
(Elsevier Science, 2016-04)
One of the most significant health problems in the American continent in terms of human health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite Trypanosoma cruzi. Infection was originally ...
In vitro and in vivo drug combination for the treatment of Trypanosoma cruzi infection: A multivariate approach
(Academic Press Inc Elsevier Science, 2018-06-16)
Combination therapies based on the available drugs have been proposed as promising therapeutic alternatives for many diseases. Clomipramine (CLO) has been found to modify the evolution of the experimental infection. The ...
Use of heparins in patients with cancer : individual participant data metaanalysis of randomised trials study protocol
(BMJ Publishing GroupGrupo de Investigación Clínica en Enfermedades del Niño y del Adolescente - PediacienciasLondres, Inglaterra, 2022)