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Functional expression and properties of a nicotinic alpha9/5-HT3A chimeric receptor
(Lippincott Williams, 2003)
Single-Channel Kinetic Analysis for Activation and Desensitization of Homomeric 5-HT3A Receptors
(Cell Press, 2009-09)
The 5-HT3A receptor is a member of the Cys-loop family of ligand-gated ion channels. To perform kinetic analysis, we mutated the 5-HT3A subunit to obtain a high-conductance form so that single-channel currents can be ...
Central serotonin and melanocortin pathways regulating energy homeostasis
(The New York Academy of Sciences, 2003-06)
It is now established that the hypothalamus is essential in coordinating endocrine, autonomic, and behavioral responses to changes in energy availability. However, the interaction of key peptides, neuropeptides, and ...
Positive regulation of raphe serotonin neurons by serotonin 2B receptors
(Nature Publishing Group, 2018-06)
Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-HT2B receptors is associated with serotonin-dependent phenotypes, including impulsivity and suicidality. A lack of 5-HT2B receptors ...
Disruption of thalamocortical activity in schizophrenia models: relevance to antipsychotic drug action
(Cambridge University Press, 2013-11)
Non-competitive NMDA receptor antagonists are widely used as pharmacological models of schizophrenia due to their ability to evoke the symptoms of the illness. Likewise, serotonergic hallucinogens, acting on 5-HT2A receptors, ...
The nervous and prenervous roles of serotonin in Echinococcus spp.
(Elsevier, 2013-03)
Serotonin (5-hydroxytryptamine, 5-HT) is an important neuroactive and morphogenetic molecule in several metazoan phyla, including flatworms. Serotoninergic nervous system studies are incomplete and 5-HT function/s are ...
Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: Genetic and pharmacological approaches
(Elsevier, 2014-01)
Previous studies from our laboratory showed that anxiety-related responses induced by nicotine (NIC), measured by the elevated plus maze, were abolished by 2-OH-saclofen (GABAB receptor antagonist) (1 mg/kg; ip) or the ...
Lorcaserin improves glycemic control via a melanocortin neurocircuit
(Elsevier Gmbh, 2017-10)
Objective: The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the ...
5-HT2a receptor in mPFC influences context-guided reconsolidation of object memory in perirhinal cortex
(eLife Sciences Publications Ltd, 2018-05)
Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is ...