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Reactions of Nifurtimox with critical sulfhydryl-containing biomolecules: Their potential toxicology relevance
(John Wiley & Sons Ltd, 2004-05)
Nifurtimox (Nfx) is a drug used in the treatment of Chagas' disease, an endemic parasitic disease from Latin American countries. It produces undesirable side-effects in patients, frequently forcing the treatment to be ...
Evaluation of the performance of an ophthalmic thermosensitive hydrogel containing combination of suramin and bevacizumab
(Bentham Science Publishers, 2016-12)
Suramab (SUM) is a new pharmaceutical combination made up of suramine (SUR) and bevacizumab (BVM), which showed a high synergistic effect when administered jointly. As the pharmaceutical vehicle, poloxamer aqueous dispersions ...
99m Tc-Radiolabeled TPGS Nanomicelles Outperform 99m Tc-Sestamibi as Breast Cancer Imaging Agent
(John Wiley & Sons Ltd, 2019-04)
D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) is a Food and Drug Administration (FDA) approved biomaterial that can form nanosized micelles in aqueous solution. TPGS micelles stand as an interesting system to ...
Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration
(Hindawi Publishing Corporation, 2017-06)
The general disruption of redox signaling following an ischemia-reperfusion episode has been proposed as a crucial component in neuronal death and consequently brain damage. Thioredoxin (Trx) family proteins control redox ...
Impairment of striatal mitochondrial function by acute paraquat poisoning
(Springer/Plenum Publishers, 2015-10)
Mitochondria are essential for survival. Their primary function is to support aerobic respiration and to provide energy for intracellular metabolic pathways. Paraquat is a redox cycling agent capable of generating reactive ...
Atrial natriuretic factor stimulates renal dopamine uptake mediated by natriuretic peptide-type A receptor
(Elsevier Science, 2005-12)
To determine the effects of atrial natriuretic factor (ANF) on renal dopamine (DA) metabolism, 3H-DA and 3H-L-DOPA uptake by renal tubular cells was measured in experiments carried out in vitro in Sprague-Dawley rats. The ...
Toxicological and therapeutic evaluation of the algae Macrocystis pyrifera (Phaeophyceae) in rodents
(Universidad de Valparaíso, 2020)
The epigenetic role of breastfeeding in mammary differentiation
(Cambridge University Press, 2020-10-07)
Maternal milk consumption can cause changes in the mammary epithelium of the offspring that result in the expression of molecules involved in the induction of differentiation, reducing the risk of developing mammary cancer ...
Conditioned effects of ethanol on the immune system
(Soc Experimental Biology Medicine, 2017-04-15)
Several studies indicate that the immune system can be subjected to classical conditioning. Acute ethanol intoxication significantly modulates several pro-inflammatory cytokines (e.g. interleukins-1 and 6 [IL-1β and IL-6, ...