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Nanodevices for Facing New Challenges of Medical Treatments: Stimuli-Responsive Drug Delivery Systems
(Medknow Publications and Media Pvt. Ltd., 2021-01)
The administration of therapeutic agents for the treatment of diseases without inclusion in a pharmaceutical formulation has been rarely reported in the current literature. In this condition, drugs show poor biodistribution ...
Drug delivery systems and liver targeting for the improved pharmacotherapy of the hepatitis B virus (HBV) infection
(Springer/Plenum Publishers, 2010-07)
In spite of the progress made in vaccine and antiviral therapy development, hepatitis B virus (HBV) infection is still the most common cause of liver cirrhosis and hepatocellular carcinoma, with more than 400 million people ...
Treatment Options for Hirsutism: A Systematic Review and Network Meta-Analysis
(Oxford University Press, 2018)
Background: Several pharmacologic treatments for hirsutism are used in practice; however, their relative efficacy is unclear. Methods: We searched MEDLINE, EMBASE, and CENTRAL through January 2017 for randomized controlled ...
Sustained Benefit of Community-based Tuberculosis Interventions after 30 Years
(American Thoracic Society, 2015)
In 1985, the overall rate of tuberculosis (TB) in Peru was 145 per 100,000 people, with higher rates seen in isolated regions in the greater Lima area. Between 1985 and 1990, the Peruvian economy shrank 10.1%; the rate of ...
Genetic Diversity of Mycobacterium tuberculosis in Peru and Exploration of Phylogenetic Associations with Drug Resistance
(Public Library of Science, 2013)
Background: There is limited available data on the strain diversity of M tuberculosis in Peru, though there may be interesting lessons to learn from a setting where multidrug resistant TB has emerged as a major problem ...
Drug delivery systems in HIV pharmacotherapy: What has been done and the challenges standing ahead
(Elsevier Science, 2009-08)
Worldwide, over 40 million people are infected with the Human Immunodeficiency Virus (HIV). The High Activity Antiretroviral Therapy (HAART) combines at least three antiretroviral (ARV) drugs and, for over a decade, has ...
Clinical evaluation of tuberculosis viability microscopy for assessing treatment response
(Oxford University Press, 2015)
BACKGROUND: It is difficult to determine whether early tuberculosis treatment is effective in reducing the infectiousness of patients' sputum, because culture takes weeks and conventional acid-fast sputum microscopy and ...
Risedronate transdermal delivery system based on a fumaric copolymer for therapy of osteoporosis
(Elsevier Science, 2017-07)
Transdermal drug delivery system (TDDS) could be seen as alternative to the oral administration which avoids several adverse effects. In this study a novel TDDS for risedronate (RI), a bisphosphonate used for osteoporosis ...
Lobomycosis successfully treated with posaconazole
(American Society of Tropical Medicine and Hygiene, 2013)
Lobomycosis is a chronic subcutaneous mycosis for which no standard treatment is available to date.We describe a patient in Peru with lobomycosis on the left earlobe that was successfully treated with posaconazolefor 27 ...