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Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice
(Springer, 2002-08)
Rationale: Dopamine (DA) D2-like antagonists block several effects of cocaine, including its locomotor stimulant and interoceptive discriminative-stimulus effects. Because these compounds generally lack selectivity among ...
Growth hormone secretagogue receptor in dopamine neurons controls appetitive and consummatory behaviors towards high-fat diet in ad-libitum fed mice
(Pergamon-Elsevier Science Ltd, 2020-09)
Growth hormone secretagogue receptor (GHSR), the receptor for ghrelin, is expressed in key brain nuclei that regulate food intake. The dopamine (DA) pathways have long been recognized to play key roles mediating GHSR effects ...
Association between serum dopamine and serum total cholesterol in dogsAsociación entre dopamina sérica y colesterol total en caninos
(Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria, 2018)
The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors
(Pergamon-Elsevier Science Ltd, 2019-03)
METH use causes neuroadaptations that negatively impact the prefrontal cortex (PFC) leading to addiction and associated cognitive decline in animals and humans. In contrast, modafinil enhances cognition by increasing PFC ...
Hydrogel-graphene oxide nanocomposites as electrochemical platform to simultaneously determine dopamine in presence of ascorbic acid using an unmodified glassy carbon electrode
(Multidisciplinary Digital Publishing Institute, 2018-12)
The detection of dopamine, an important neurotransmitter in the central nervous system, is relevant because low levels of dopamine can cause brain disorders. Here, a novel electrochemical platform made of a hydrogel–graphene ...
Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling
(Cell Press, 2016-05)
Bradykinesia is a prominent phenotype of Parkinson's disease, depression, and other neurological conditions. Disruption of dopamine (DA) transmission plays an important role, but progress in understanding the exact mechanisms ...
Piribedil for the Treatment of Motor and Non-motor Symptoms of Parkinson Disease
(Adis Int Ltd, 2016-08)
Dopamine agonists are well-established symptomatic medications for treating early and advanced Parkinson disease (PD). Piribedil was one of the first agonists to be marketed (1969) and is widely used as an extended-release ...
The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
(Wiley Blackwell Publishing, Inc, 2001-03)
According to the dual systems model for opiate reward, dopamine mediates opiate motivation when an animal is in a deprived motivational state (i.e. opiate-dependent and in withdrawal) and not when an animal is in a nondeprived ...
Rotigotine transdermal delivery for the treatment of Parkinson's disease
(Informa Healthcare, 2009-03)
Background: Rotigotine is a non-ergot dopamine agonist that has been developed as a new transdermal formulation, and is indicated for use in early (USA and Europe) and advanced (Europe only) Parkinson's disease (PD). The ...
Dopamine Regulation of Lateral Inhibition between Striatal Neurons Gates the Stimulant Actions of Cocaine
(Cell Press, 2016-06)
Striatal medium spiny neurons (MSNs) form inhibitory synapses on neighboring striatal neurons through axon collaterals. The functional relevance of this lateral inhibition and its regulation by dopamine remains elusive. ...