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Junin virus triggers macrophage activation and modulates polarization according to viral strain pathogenicity
(Frontiers Media S.A., 2019-10)
The New World arenavirus Junin (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF). Previous studies of human macrophage infection by the Old-World arenaviruses Mopeia and Lassa showed that while the ...
Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages
(American Physiological Society, 2014-09)
Endoplasmic reticulum (ER) stress is a prominent mechanism of macrophage apoptosis in advanced atherosclerotic lesions. Recent studies from our laboratory showed that advanced atherosclerotic plaques in Apoe-/- mice with ...
M1-like macrophage polarization prevails in young children with classic Hodgkin Lymphoma from Argentina
(Nature Publishing Group, 2019-09)
The microenvironment in classical Hodgkin lymphoma (cHL) comprises a mixture of different types of cells, which are responsible for lymphoma pathogenesis and progression. Even though microenvironment composition in adult ...
PD-1/PD-L1 Pathway Modulates Macrophage Susceptibility to Mycobacterium tuberculosis Specific CD8+ T cell Induced DeathPD-1/PD-L1 Pathway Modulates Macrophage Susceptibility to Mycobacterium tuberculosis Specific CD8+ T cell Induced Death
(Nature Publishing GroupNature Publishing Group, 2019-01)
CD8+T cells contribute to tuberculosis (TB) infection control by inducing death of infected macrophages. Mycobacterium tuberculosis (Mtb) infection is associated with increased PD-1/PD-L1 expression and alternative activation ...
Transcriptional profiling of human macrophages during infection with Bordetella pertussis
(Landes Bioscience, 2020-02-19)
Bordetella pertussis, a strictly human re-emerging pathogen and the causative agent of whooping cough, exploits a broad variety of virulence factors to establish efficient infection. Here, we used RNA sequencing to analyse ...
“Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice”
(Elsevier Science, 2020-07)
Spexin (SPX) is a novel adipokine related to many metabolic effects, such as gastrointestinal movements, insulinand glucose homeostasis, lipid metabolism and energy balance. This study evaluates the role of SPX in theimprovement ...
4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice
(Nature, 2021-12)
Hepatocellular carcinoma (HCC) arises in the setting of advanced liver fibrosis, a dynamic and complex inflammatory disease. The tumor microenvironment (TME) is a mixture of cellular components including cancer cells, ...
Second generation BTK inhibitors impair the anti-fungal response of macrophages and neutrophils
(Wiley-liss, div John Wiley & Sons Inc., 2020-04)
BTK inhibitors (BTKi) play a major role in the treatment of Chronic Lymphocytic Leukemia (CLL). Ibrutinib, the first in class BTKi, impairs macrophage and neutrophil functions and also cell-mediated effector mechanisms of ...
Nebulizing novel multifunctional nanovesicles: The impact of macrophage-targeted-pH-sensitive archaeosomes on a pulmonary surfactant
(Royal Society of Chemistry, 2017-09)
In this study, a NE-U22 vibrating mesh Omron nebulizer was used to deliver the Lissamine™ rhodamine B 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine triethylammonium salt (Rh-PE) and 8-hydroxypyrene-1,3,6-trisulfonic ...
Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines
(Elsevier, 2015)
A series of original 2-phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyrazines and the 3-iodo precursors, bearing a polar moiety at the C-8 position, was synthesized and evaluated for their antileishmanial activities. Two derivatives ...