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VEGF and CD31 association in pituitary adenomas
(Humana Press, 2010-09)
Pituitary tumors are usually less vascularized than the normal pituitary, and the role of angiogenesis in these adenomas is contentious. Appraisal of microvascular density and expression of the potent angiogenic vascular ...
Molecular and cellular pathogenesis of pituitary tumors
(Elsevier, 2018-08)
Pituitary tumors occur sporadically (95%) or as hereditary tumors, either associated with endocrine syndromes (2.5%) or as familial isolated variants (FIPA, 2.5%). In sporadic pituitary tumors, in addition to the known ...
Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
(BioScientifica, 2012-09)
Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human ...
Novel Medical Therapies for Pituitary Tumors
(Karger, 2010-07)
Despite considerable progress, there is still no medical treatment available for some kinds of pituitary tumors, in particular hormone inactive adenomas and corticotroph pituitary tumors. Surgical removal or at least ...
Intracellular distribution of GABA in the rat anterior pituitary. An electron microscopic autoradiographic study
(Harcourt Publishers, 2000-04)
We studied the internalization and intracellular distribution of [3H] GABA in rat anterior pituitary cells. Electron microscopic autoradiography of anterior pituitary fragments or dispersed pituitary cells incubated with[3H] ...
Programmed cell senescence: Role of IL-6 in the pituitary
(BioScientifica, 2017-05)
IL-6 is a pleiotropic cytokine with multiple pathophysiological functions. As a key factor of the senescence secretome, it can not only promote tumorigenesis and cell proliferation but also exert tumor suppressive functions, ...
Association of PTP4A3 expression and tumour size in functioning pituitary adenoma: A descriptive study
(B M J Publishing Group, 2021-03)
PTP4A3 is a subclass of a protein tyrosine phosphatase super family and is expressed in a range of epithelial neoplasms. We evaluated PTP4A3 expression and its association with clinical-pathological parameters in different ...
Inhibition of Notch signaling attenuates pituitary adenoma growth in Nude mice
(BioScientifica, 2018-08)
Preclinical and clinical studies support that Notch signaling may play an important oncogenic role in cancer, but there is scarce information for pituitary tumors. We therefore undertook a functional study to evaluate Notch ...