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Synthesis of Carbolines by Photostimulated Cyclization of Anilinohalopyridines
(American Chemical Society, 2011-08)
A general synthetic route to prepare all four carboline regioisomers by photostimulated cyclization of anilinohalopyridines is described. The methodology affords various substituted carbolines in good to excellent yields. ...
Photophysical and spectroscopic features of 3,4-dihydro-β-carbolines: A combined experimental and theoretical approach
(Royal Society of Chemistry, 2020-09)
3,4-Dihydro-β-carbolines (DHβCs) are a set of endogenously synthesized alkaloids spread over a great variety of living species (e.g., plants, animals and microorganisms), playing a broad spectrum of biological, biochemical ...
Mechanisms of DNA damage by photoexcited 9-methyl-β-carbolines
(Royal Society of Chemistry, 2013-06-18)
It has been well documented that β-carboline alkaloids, particularly the 9-methyl derivatives, are efficient photosensitizers. However, structure–activity relationships are missing and the photochemical mechanisms involved ...
In vitro evaluation of β-carboline alkaloids as potential anti-Toxoplasma agents
(BioMed Central, 2013-05)
Background: Toxoplasmosis is a worldwide infection caused by the protozoan parasite Toxoplasma gondii, which causes chorioretinitis and neurological defects in congenitally infected newborns or immunodeficient patients. ...
β-Carboline derivatives as novel antivirals for herpes simplex virus
(Elsevier Science, 2018-10)
Several commercial and novel synthetic β-carbolines (βCs) were evaluated for their antiviral activity against herpes simplex virus type 1 (HSV-1) using an adapted MTS assay. Of 21 drugs tested, although 11 exerted antiviral ...
Intra- and extracellular DNA damage by harmine and 9-methyl-harmine
(Elsevier Science Sa, 2014-02-13)
It is known that b-carbolines are able to produce photosensitized damage in cell-free DNA, but there is little information on their effects on cellular DNA. Therefore, we have analyzed the DNA damage produced by harmine ...
N-methyl-β-carboline alkaloids: structure-dependent photosensitizing properties and localization in subcellular domains
(Royal Society of Chemistry, 2020-07)
N-methyl-Beta-carboline (bC) alkaloids, including normelinonine F and melinonine F, have been found in a vast range of living species playing different biological, biomedical and/or pharmacological roles. Despite this, ...
1-Substituted β-carbolines by a Pictet-Spengler cyclization with thioortho esters and carbon-carbon bond formation via N-sulfonyl iminium ions generated from N,S-sulfonyl acetals
(American Chemical Society, 2005-08)
(Chemical Equation Presented) The reaction of N-tosyltryptamines with thioortho esters, leading to 1-thiosubstituted tetrahydro-β-carbolines under modified Pictet-Spengler conditions, is described. The 1-heterosubstituted ...
DNA damage induced by photoexcited bare and loaded Microporous Coordination Polymers
(Royal Society of Chemistry, 2015-05)
We report on interactions of cell free double-stranded DNA (dsDNA) with a selected subgroup of Microporous Coordination Polymers (MCPs). In particular, we have studied the influence of different metal ion constituents and ...