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CD32 ligation promotes the activation of CD4+T cells
(Frontiers Media SA, 2018-11)
Low affinity receptors for the Fc portion of IgG (FcγRs) represent a critical link between innate and adaptive immunity. Immune complexes (ICs) are the natural ligands for low affinity FcγRs, and high levels of ICs are ...
Phenotypic characterisation of the cellular immune infiltrate in placentas of cattle following experimental inoculation with Neospora caninum in late gestation
(BMC, 2013-07)
Despite Neospora caninum being a major cause of bovine abortion worldwide, its pathogenesis is not completely understood. Neospora infection stimulates host cell-mediated immune responses, which may be responsible for the ...
Vasoactive intestinal peptide shapes first-trimester placenta trophoblast, vascular, and immune cell cooperation
(Wiley Blackwell Publishing, Inc, 2019-04)
Background and Purpose: Extravillous trophoblast (EVT) cells are responsible for decidual stromal invasion, vascular transformation, and the recruitment and functional modulation of maternal leukocytes in the first-trimester ...
Dendritic cells exposed to triiodothyronine deliver pro-inflammatory signals and amplify IL-17-driven immune responses
(Karger, 2019-07)
Although a cross-talk between immune and endocrine systems has been well established, the precise pathways by which these signals co-regulate pro- and antiinflammatory responses on antigen-presenting cells remain poorly ...
Harnessing tumor necrosis factor alpha to achieve effective cancer immunotherapy
(MDPI, 2021-02)
Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine known to have contradictory roles in oncoimmunology. Indeed, TNFα has a central role in the onset of the immune response, inducing both activation and the effector ...
Effect of nitric oxide inhibition in Bacillus Calmette-Guerin bladder cancer treatment
(Academic Press Inc Elsevier Science, 2020-05)
Background: Bacillus Calmette-Guerin (BCG) is the standard treatment for patients with high-risk non-muscle invasive bladder cancer (BC). Despite its success, about 30–50% of patients are refractory. It was reported that ...
Liver infiltrating mononuclear cells in children with type 1 autoimmune hepatitis
(B M J Publishing Group, 2006-12)
Objective: To investigate infiltrating cells in the liver of children with type 1 autoimmune hepatitis (AH-1). Methods: liver biopsies from 24 untreated AH-1 patients (14 children, 10 adults), five patients with hepatitis ...
Reduced glioma growth following dexamethasone or anti-angiopoietin 2 treatment
(Wiley Blackwell Publishing, Inc, 2008-07)
All patients with glioblastoma, the most aggressive and common form of brain cancer, develop cerebral edema. This complication is routinely treated with dexamethasone, a steroidal anti-inflammatory drug whose effects on ...
Non-Viable Lactobacillus Casei Beneficially Modulates Poly I:C Immune Response in Co-Cultures of Human Cells
(Shiraz Inst Cancer Res, 2017-12)
Background: Polyinosinic:polycytidylic acid (Poly-IC) has been used as a viralstimulus to mimic in vivo and in vitro infection induced by some viruses. Objective: To determine whether non-viable Lactobacillus casei CRL431 ...
Lipoteichoic acid is involved in the ability of the immunobiotic strain lactobacillus plantarum CRL1506 to modulate the intestinal antiviral innate immunity triggered by TLR3 activation
(Frontiers Media S.A., 2020-04-09)
Studies have demonstrated that lipoteichoic acid (LTA) is involved in the immunomodulatory properties of some immunobiotic lactobacilli. The aim of this work was to evaluate whether LTA contributes to the capacity of ...