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Activity of intestinal efflux pumps in M-406 mammary adenocarcinoma bearing mice with metabolic syndrome treated with cyclophosphamide metronomic chemotherapy
(Fundación Revista Medicina, 2019)
High fat diet (HFD) cause obesity and MS, which are associated with breast cancer progression. MC (chronic, low dose, with no extended rest periods, drug administration) is a promising treatment strategy with low toxicity. ...
Scanning electron microscopy analysis of hair treated with pyloric cecae extract from pacu (Piaractus mesopotamicus)
(Fundación Revista Medicina, 2019)
Hair is composed mainly of keratin (90%) is a fibrous and insoluble protein with high content of amino acid cysteine, responsible of disulfide bonds presence, which gives it high resistance to degradation. Hair structure ...
Dynamics of soluble immune mediators in COVID-19 patients from an Argentinean cohort with moderate and severe symptoms
(Sociedad Argentina de Inmunología, 2021)
The cytokine storm, a form of systemic inflammatory response syndrome, is one of the most dreadful complications that can occur during COVID-19. The severity of infection is associated at different levels of these immune ...
Meropenen inhibits the cytochrome P450 (CYP) 3A-dependent biotransformation of the immunosuppressive tacrolimus in human liver microsomes
(Fundación Revista Medicina, 2021)
Tacrolimus (TAC), a immunosuppressive drug used in solid organ transplantation, is metabolized by CYP3A4 and 3A5. The simultaneous administration of TAC and meropenem (MEP) in pediatric kidney transplant patients may led ...
Phenotype and functional alterations of human NK cells by organophosphate pesticides
(Fundación Revista Medicina, 2021)
Chlorpyrifos (CPF) and Glyphosate (GLY) are organophosphate pesticides widely used in agriculture. Several evidences suggest that CPF- and GLY-based pesticides are genotoxic and their use has been linked to the increased ...
Assessment of resistance patterns of antimicrobials with high importance in human health, in diagnosed bovine neumonia
(Medicina (Buenos Aires), 2019)
Bovine respiratory disease (BRD) is themost important illness in feedlot cattle, where animals aresubjected to high pharmacological pressure with antimicrobial(ATM) drugs for prevention or treatment. Some of ATM used ...
Functional roles of AMP-activated protein kinase (AMPK) complexes containing TcAMPKα1 or TcAMPKα2 in energy homeostasis regulation and cell culture progression in Trypanosoma cruzi
(Fundación Revista Medicina, 2019)
The AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme involved in maintaining energy homeostasis in response to different stresses in many organisms. During the transition between the mammalian host and the ...
Alterations of blood immune cells in COVID-19 elderly patients with or without type 2 diabetes
(Fundación Revista Medicina, 2021)
Elderly individuals, especially those with pre-existing conditions like diabetes mellitus (DM), have a high risk for developing severe cases of COVID-19. The aim of this work was to characterize the alterations of blood ...
Estrogen receptor and endothelial dysfunction
(Fundacion Revista Medicina, 2019)
Estrogen receptor (ER) plays key role on vascular homeostasis. Alterations of ER signaling could conduct to vascular dysfunction, impairment of angiogenesis and platelet aggregation and activation. Preeclampsia (PE) is a ...
Effect of social isolation due to COVID-19 on BMI in school children
(Medicina (Buenos Aires), 2021)
Introduction: Preventive and compulsory social isolation (ASPO) and the resulting closure of schools and suspension of sports practice reduced physical activity; this could affect children causing changes in lifestyle and ...